Plasma metabolite biomarkers related to secondary hyperparathyroidism and parathyroid hormone. Issue 9 (8th May 2019)

• Record Type: Journal Article
• Authors: Shen, Qixia; Xiang, Wenyu; Ye, Sen; Lei, Xin; Wang, Lefeng; Jia, Sha; Shao, Xue; Weng, Chunhua; Shen, Xiujin; Wang, Yucheng; Feng, Shi; Qu, Lihui; Wang, Cuili; Chen, Jianghua; Zhang, Ping; Jiang, Hong
• Is Part Of: Journal of cellular biochemistry. Volume 120:Issue 9(2019)
• Page Start: 15766
• Page End: 15775
• Publication Date: 2019-05-08
• Subjects: end‐stage renal disease -- long‐term dialysis -- metabolites -- parathyroid hormone -- secondary hyperparathyroidism; Cytochemistry -- Periodicals; 572
• DOI: 10.1002/jcb.28846
• Languages: English
• ISSNs: 0730-2312

Abstract

Abstract: Background: Hyperphosphatemia, hypocalcemia, and elevation of parathyroid hormone (PTH) are typical abnormalities of uremic patients with Secondary hyperparathyroidism (SHPT). However, metabolic imbalance associated with SHPT is not well understood. Methods: A total of 15 SHPT patients with an intact parathyroid hormone (iPTH) level > 600 pg/mL were set as preoperative (PR) group, 15 age‐ and gender‐matched controls who had undergone parathyroidectomy plus forearm transplantation because of hyperparathyroidism and achieved an iPTH level <150 pg/mL were set as postoperative (PO) group. Metabolite profiling of these 30 uremic patients and five healthy controls (HC) was performed using ultra performance liquid chromatography‐mass spectrometry. Results: Five differential metabolites, including allyl isothiocyanate, L ‐phenylalanine, D ‐Aspartic acid, indoleacetaldehyde, and D ‐galactose correlated with PTH were identified in this study. Taking them as a biomarker signature, PR group can be distinguished from HC group with an area under the curve (AUC) of 0.947 (95% CI, 0.76‐1) and PO group with an AUC of 0.6 (95% CI, 0.38‐0.807). Conclusions: The serum metabolome correlated with PTH is successfully demonstrated for a better understanding of the pathogenesis of SHPT. Abstract : We find Five differential metabolites, including allyl isothiocyanate, l ‐phenylalanine, d ‐apartic acid, indoleacetaldehyde, and d ‐galactose correlated with PTH. Taking them as a biomarker signature, SHPT patients can be distinguished from healthy controls or those who had undergone parathyroidectomy.