Immune profiling after minimally invasive lobectomy. (12th December 2020)

• Record Type: Journal Article
• Authors: Erus, Suat; Öztürk, Ayşe Bilge; Albayrak, Özgür; İncir, Said; Kapdağlı, Murat Hüseyin; Cesur, Ekin Ezgi; Yavuz, Ömer; Tanju, Serhan; Dilege, Şükrü
• Is Part Of: Interactive cardiovascular and thoracic surgery. Volume 32:Number 2(2021)
• Page Start: 291
• Page End: 297
• Publication Date: 2020-12-12
• Subjects: Early-stage lung cancer -- Minimally invasive surgery -- Natural killer -- Tumour necrosis factor alpha -- Interleukin 8 -- Interleukin 10; Chest -- Surgery -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; 616.1
• DOI: 10.1093/icvts/ivaa296
• Languages: English
• ISSNs: 1569-9293

Abstract

Abstract: OBJECTIVES: Whether acute phase and immune responses are minimally affected following minimally invasive lung surgery needs further investigation. We performed a pilot study to evaluate the immune profile of patients who underwent video-assisted thoracoscopic surgery or robot-assisted thoracic surgery lobectomies for the treatment of suspicious or known stage I non-small-cell lung cancer. METHODS: Blood samples were taken preoperatively and 3 and 24 h postoperatively were analysed for C-reactive protein, glucose, cortisol, tumour necrosis factor alpha (TNF-α), interleukin 8 (IL-8) and interleukin 10 (IL-10) levels. TNF-α, IL-8 and IL-10 were also measured in lung tissues. T (CD4, CD8), B (CD19) and natural killer (CD56, CD16) cell counts and natural killer cell functions were analysed using a flow cytometry-based assay before and after surgery. RESULTS: Minimally invasive surgery (robot-assisted thoracic surgery + video-assisted thoracoscopic surgery) significantly decreased IL-10 ( P = 0.016) levels after surgery. No significant differences were detected in TNF-α ( P = 0.48) and IL-8 ( P = 0.15) levels before and after surgery. C-reactive protein ( P < 0.001), cortisol ( P < 0.001) and glucose levels ( P < 0.001) increased significantly after surgery. Lymphocyte, total T cell, CD3 + CD4 + and CD3 + CD8 + CD16 + CD56 + cell counts were significantly lower on postoperative day 1. CONCLUSION: There seems to be a dynamic balance between pro- and anti-inflammatory cytokines and immune cells following minimally invasive lobectomy. Abstract : Along with the improvements in endoscopic video systems and endoscopic staplers, minimally invasive surgery has become more popular in the treatment of early-stage lung cancer.