Childhood Maltreatment and Psychiatric Comorbidity in Immune-Mediated Inflammatory Disorders. Issue 1 (January 2022)

• Record Type: Journal Article
• Authors: Wan, Anthony; Bernstein, Charles N.; Graff, Lesley A.; Patten, Scott B.; Sareen, Jitender; Fisk, John D.; Bolton, James M.; Hitchon, Carol; Marriott, James J.; Marrie, Ruth Ann
• Is Part Of: Psychosomatic medicine. Volume 84:Issue 1(2022)
• Publication Date: 2022-01
• Subjects: adverse childhood experiences -- childhood maltreatment -- autoimmune diseases -- depression -- anxiety -- ACE = adverse childhood experience -- CD = Crohn disease -- CI = confidence interval -- CRP = C-reactive protein -- CTQ = Childhood Trauma Questionnaire -- EA = emotional abuse -- EN = emotional neglect -- HADS-A = Hospital Anxiety and Depression Scale—Anxiety -- HADS-D = Hospital Anxiety and Depression Scale—Depression -- IBD = inflammatory bowel disease -- IMID = immune-mediated inflammatory disorder -- IL-6 = interleukin-6 -- MDD = major depressive disorder -- MS = multiple sclerosis -- OR = odds ratio -- PA = physical abuse -- PN = physical neglect -- RA = rheumatoid arthritis -- SA = sexual abuse -- SCID-IV = Structured Clinical Interview for DSM-IV -- UC = ulcerative colitis; Medicine, Psychosomatic -- Periodicals; 616.0805
• DOI: 10.1097/PSY.0000000000001025
• Languages: English
• ISSNs: 0033-3174

Abstract

ABSTRACT: Objective: To determine whether childhood maltreatment is associated with immune-mediated inflammatory disorders (IMIDs; multiple sclerosis [MS], inflammatory bowel disease [IBD], and rheumatoid arthritis [RA]). We further aimed to determine the relationship between maltreatment and psychiatric comorbidity in IMIDs and whether these relationships differed across IMID. Methods: Six hundred eighty-one participants (MS, 232; IBD, 216; RA, 130; healthy controls, 103) completed a structured psychiatric interview to identify psychiatric disorders, and the Childhood Trauma Questionnaire to evaluate five types of maltreatment: emotional abuse, physical abuse, sexual abuse, emotional neglect, and physical neglect. We evaluated associations between maltreatment, IMID, and psychiatric comorbidity using multivariable logistic regression models. Results: The prevalence of having ≥1 maltreatment was similar across IMID but higher than in controls (MS, 63.8%; IBD, 61.6%; RA, 62.3%; healthy controls, 45.6%). Emotional abuse was associated with having an IMID (adjusted odds ratio [aOR] = 2.37; 1.15–4.89). In the sex-specific analysis, this association was only present in women. History of childhood maltreatment was associated with a lifetime diagnosis of a psychiatric disorder in the IMID cohort (OR = 2.24; 1.58–3.16), but this association did not differ across diseases. In those with IMID, total types of maltreatments (aOR = 1.36; 1.17–1.59) and emotional abuse (aOR = 2.64; 1.66–4.21) were associated with psychiatric comorbidity. Conclusions: Childhood maltreatment is more common in IMID than in a healthy population and is associated with psychiatric comorbidity. Given the high burden of psychiatric disorders in the IMID population, clinicians should be aware of the contribution of maltreatment and the potential need for trauma-informed care strategies. Abstract : Supplemental digital content is available in the text.