GW24-e2371 The association between KCNJ5 gene polymorphism and primary aldosteronism. (1st October 2013)

• Record Type: Journal Article
• Authors: Chao, Shi; Hongjian, Li; Feiya, Zu; Delian, Zhang; Guijuan, Chang; Nanfang, Li
• Is Part Of: Heart. Volume 99(2013)Supplement 3
• Page Start: A62
• Page End: A62
• Publication Date: 2013-10-01
• Subjects: Heart -- Diseases -- Treatment -- Periodicals; Cardiology -- Periodicals; 616.12
• DOI: 10.1136/heartjnl-2013-304613.172
• Languages: English
• ISSNs: 1355-6037

Abstract

Abstract : Objectives: To investigate the association of rs1221497 in KCNJ5 gene and primary aldosteronism (PA). KCNJ5 is a gene encoding a G-protein-coupled inwardly rectifying potassium. Methods: A total of 218 PA patients and 853 essential hypertension (EH) patients was enrolled in this study, taqMan assay was used to detect the rs1221497 polymorphism of KCNJ5 gene. Results: The genotypes of rs1221497 were in H-W equilibrium in both PA group and EH group, the genotype frequencies of GG, GC, CC were 208, 39, 1 in PA group and 631, 177, 8 in EH group; the allele frequencies in the two group were 455, 41 and 1439, 193 respectively. The distribution of GG genotype and G allele differ significantly between PA group and EH group. Logistic regression showed that GG genotype was also associated with PA after adjusting age. Conclusions: GG genotype and G allele may contribute to the occurrence of PA.