GW24-e3717 Relationship between PAI-1 promotor region gene 4G/5G polymorphism and pulmonary thromboembolism. (1st October 2013)

• Record Type: Journal Article
• Authors: Hanying, Ma; Hong-ya, Han; Qing, Yang; Nie-Bin, ; Rui-fang, Liu; Meng, Chai; Ou, Zhang; Wen, Guo; Yu-jie, Zhou
• Is Part Of: Heart. Volume 99(2013)Supplement 3
• Page Start: A65
• Page End: A65
• Publication Date: 2013-10-01
• Subjects: Heart -- Diseases -- Treatment -- Periodicals; Cardiology -- Periodicals; 616.12
• DOI: 10.1136/heartjnl-2013-304613.179
• Languages: English
• ISSNs: 1355-6037

Abstract

Abstract : Objectives: To investigate the relationship between plasminogen activator inhibitor-1(PAI-1) promotor region gene 4G/5G polymorphism and pulmonary thromboembolism (PTE) and detect whether it plays an important role in the pathogenesis of pulmonary thromboembolism. Methods: Fifty-eight patients with PTE and 57 sex and age matched healthy controls were recruited in this study. Genome DNA was extracted from whole blood using phenol-chloroform. Subjects were genotyped for the 4G/5G polymorphism of PAI-1 gene using polymerase chain reaction based restriction fragment length polymorphism analysis. Results: Significant differences were found in the frequencies of genotype 4G/4G, 4G/5G and 5G/5G. The recessive allele model was informative and the odd ratio of 4G/4G genotype was much higher compared with that of other two genotypes. After further stratification, we found that 4G/4G genotype was bound to be associated with high risk of PTE for those individuals without existing traditional environment risk factors. Conclusions: This study shows that 4G/5G polymorphism of PAI-1 gene is associated with PTE and 4G allele is recessive. Our results indicates that 4G/4G genotype increases the risk of PTE for individuals who have no traditional risk factors of PTE.