Air pollution and neighborhood racial composition and their association with memory and memory decline in NHATS. (31st December 2021)

• Record Type: Journal Article
• Authors: Dang, Kristina; Weuve, Jennifer; Haan, Mary; Allen, Isabel Elaine; Brauer, Michael; Lane, Kevin; Glymour, M Maria
• Is Part Of: Alzheimer's & dementia. Volume 17(2021)Supplement 10
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-12-31
• Subjects: Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1002/alz.054965
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: Background: Memory decline is a harbinger of Alzheimer's disease (AD). Air pollution was recently added as a dementia risk factor by the Lancet Commission, and area‐level factors, such as neighborhood racial composition (a measure of structural racism) may modify the effects of air pollution. We examined the relationship between air pollution and neighborhood racial composition on memory and decline in a sample of older adults in the United States. Method: NHATS is a nationally‐representative sample of 8, 245 participants 65+ years at baseline (2011). Annual averages of fine particulate matter (PM2.5, IQR = 2.2 μg/m 3 ), nitrogen dioxide (NO2, IQR = 5.5 ppb), and ozone (O3, IQR = 8.4 ppb) at baseline and Census ACS data were assigned to the Census tract of participants. The Index of Concentration at the Extremes, defined as: [(number in most disadvantaged extreme, i.e., Blacks) ‐ (number in most privileged extreme, i.e., Whites)]/(total people) was calculated for each census tract as a measure of neighborhood racial composition. A composite measure of episodic memory was constructed as the average of z‐scored delayed and immediate word list recall. We used linear mixed effects models to examine the association between each air pollutant and neighborhood racial composition with memory and memory decline over 6 years, adjusting for a number of individual‐ (age, race/ethnicity, gender, education, smoker, practice effects) and area‐ (census division, urban tract) level covariates, with random effects for census tract and participant. Result: Increases in air pollution (per IQR) were weakly associated with worse memory at baseline [PM2.5 ‐0.02 (95% CI: ‐0.05, 0.006); NO2 ‐0.03 (‐0.06, 0.002); O3 ‐0.03 (‐0.06, ‐0.0004) SD‐units in memory]. PM2.5 increased the rate of memory decline by ‐0.01 (‐0.02, ‐0.0008); while NO2 increased the rate of memory decline by ‐0.008 (‐0.01, ‐0.0007). Neighborhood racial composition was significantly associated with worse memory (for more disadvantaged neighborhoods) in all air pollution models, but it did not modify the effect of air pollution on memory nor memory decline. Conclusion: In this cohort of older adults, we found that PM2.5 and NO2 increase the rate of memory decline, while neighborhood racial composition does not modify this effect of air pollution.