Erythropoietin Concentration in Boys With p.His63Asp Polymorphism of the HFE Gene. Issue 1 (January 2022)

• Record Type: Journal Article
• Authors: Kaczorowska-Hac, Barbara; Luszczyk, Marcin; Wasilewska, Eliza; Antosiewicz, Jedrzej; Kaczor, Jan J.
• Is Part Of: Journal of pediatric hematology/oncology. Volume 44:Issue 1(2022)
• Publication Date: 2022-01
• Subjects: HFE gene -- hemoglobin -- erythropoietin -- children; Pediatric hematology -- Periodicals; Tumors in children -- Periodicals; 618.9215
• DOI: 10.1097/MPH.0000000000002126
• Languages: English
• ISSNs: 1077-4114

Abstract

Abstract : The molecular mechanism that regulates iron homeostasis is based on a network of signals, which reflect on the iron requirements of the body. HFE -related hemochromatosis is characterized by excessive intestinal absorption of dietary iron, in particular cases resulting in pathologically high iron storage in tissues and organs. During childhood, HFE gene homozygosity or heterozygosity manifests exclusively in the form of biochemical abnormalities. Because of their mutual link, bioavailable iron and endogenous erythropoietin (EPO) are indispensable for effective erythropoiesis. We analyzed the impact of p.(His63Asp) polymorphism of the HFE gene on erythropoiesis taking into consideration endogenous EPO production in the developmental age. In the study we performed, we observed a significant, strong and negative correlation between the concentration of EPO, hemoglobin, and red blood cell count. A negative trend was also noted on the impact of iron concentration and transferrin saturation on EPO production. In conclusion, this preliminary study demonstrates an impaired impact of endogenous EPO on erythropoiesis in the presence of increased iron content in carriers of p.(His63Asp) (heterozygotes) variant of the HFE gene in developmental age.