Analysis of RNA m6A methylation regulators and tumour immune cell infiltration characterization in prostate cancer. Issue 1 (1st January 2021)

• Record Type: Journal Article
• Authors: Zhao, Yue; Sun, Huimin; Zheng, Jianzhong; Shao, Chen
• Is Part Of: Artificial cells, nanomedicine, and biotechnology. Volume 49:Issue 1(2021)
• Page Start: 407
• Page End: 435
• Publication Date: 2021-01-01
• Subjects: Prostate cancer -- m6A RNA methylation -- tumour microenvironment -- prognosis -- immune cell infiltration; Artificial cells -- Periodicals; Nanotechnology -- Periodicals; Blood substitutes -- Periodicals; Tissue engineering -- Periodicals; Molecules -- Periodicals; Biotechnology -- Periodicals; 615.39
• DOI: 10.1080/21691401.2021.1912759
• Languages: English
• ISSNs: 2169-1401

Abstract

Abstract: Potential roles of RNA N6-methyladenosine (m 6 A) modification in tumour microenvironment (TME) cell infiltration has been demonstrated in recent studies. Nonetheless, the mechanism of its regulation remains unknown and immunotherapy has been marginal in prostate cancer. We demonstrated the expression of different m 6 A regulators within prostate cancer related to genetic variation, alternative splicing (AS), tumour mutational burden (TMB) and TME. Unsupervised clustering and risk prediction model constructed by 24 m 6 A regulators could predict scores of TME and prostate cancer patients prognosis. T cells CD8 was the intersection of immune cells which are related to multiple biological processes, and the fraction of T cells CD8 strongly correlates with immune associated gene sets. m 6 A methylation modification and immune cells infiltration played a nonnegligible role in prostate cancer. Our study represents a step towards personalized immunotherapy for prostate cancer patients.