Diversity of lymphatic flow in patients with lung cancer revealed by computed tomography lymphography. (28th July 2021)

• Record Type: Journal Article
• Authors: Kawakami, Yukikiyo; Takizawa, Hiromitsu; Toba, Hiroaki; Kawakita, Naoya; Yoshida, Mitsuteru; Kondo, Kazuya; Tangoku, Akira
• Is Part Of: Interactive cardiovascular and thoracic surgery. Volume 33:Number 6(2021)
• Page Start: 871
• Page End: 878
• Publication Date: 2021-07-28
• Subjects: Lung cancer -- Lymph node dissection -- Sentinel lymph node -- CT lymphography; Chest -- Surgery -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; 616.1
• DOI: 10.1093/icvts/ivab204
• Languages: English
• ISSNs: 1569-9293

Abstract

Abstract: : OBJECTIVES: This study was conducted to verify the optimal extent of lymph node dissection or sampling during lung cancer surgery based on the sentinel node (SN) map created by computed tomography (CT) lymphography. METHODS: From April 2010 to January 2015, patients with clinical stage I non-small-cell lung cancer, who were candidates for lobectomy or segmentectomy with standard hilar and mediastinal lymph node dissection, and in whom bronchus reached the tumour, were enrolled. An ultrathin bronchoscope was inserted to the target bronchus under the guidance of virtual bronchoscopic navigation images. CT images of the chest were obtained 30 s after 2.5 ml of iopamidol was injected. SNs were identified when the maximum CT attenuation value of the lymph nodes on postcontrast CT images increased by 30 Hounsfield units or more compared with the precontrast images. Patients underwent lobectomy with standard lymph node dissection. RESULTS: SNs were identified in 36 (87.8%) of the 41 patients. The average number of SNs was 1.6 (range, 1–4). There was 1 false negative case; therefore, the accuracy of SN identification was 97.2% (35/36). In 5 (13.9%) of 36 patients, SNs were outside the lobe-specific lymph node station range (#11i from right S 1, #7 from right S 1, #4R from right S 8, #12u from right S 8, #7 and #12l from left S 1 + 2 ). CONCLUSIONS: CT lymphography demonstrated the diversity of lymphatic spreading patterns and there were cases in which lymph flows are found outside the lymph node dissection range. Abstract : Accurate lymph node staging is essential to improve outcomes of lung cancer treatment because lymph node metastasis is a powerful prognostic factor [1].