Evaluation of risk factors for and subsequent mortality from poor graft function (PGF) post allogeneic stem cell transplantation. Issue 6 (12th May 2021)

• Record Type: Journal Article
• Authors: Prabahran, Ashvind; Koldej, Rachel; Chee, Lynette; Wong, Eric; Ritchie, David
• Is Part Of: Leukemia & lymphoma. Volume 62:Issue 6(2021)
• Page Start: 1482
• Page End: 1489
• Publication Date: 2021-05-12
• Subjects: Poor graft function -- complications -- allogeneic stem cell transplantation; Leukemia -- Periodicals; Lymphomas -- Periodicals; 616.99419
• DOI: 10.1080/10428194.2021.1872072
• Languages: English
• ISSNs: 1042-8194

Abstract

Abstract: Poor Graft Function (PGF) is defined by multi-lineage cytopenias with complete donor chimerism post allogeneic transplantation, Risk factors for and subsequent mortality from PGF were assessed in our transplant cohort. Non-sibling donor [OR 1.97; 95% CI 1.02–3.70], ICU admission [OR 5.28; 95% CI 2.29–11.88] or blood culture positivity within the first 30 days [OR 1.67; 95% CI 1.07–2.62], grade III–IV acute graft vs host disease (GVHD) [OR 4.082; 95% CI 2.31–7.16] and CMV viremia [OR 2.43; 95% CI 1.53–3.88] and were significantly associated with development of PGF. PGF patients without count recovery had a 2 year OS of 6%. Severe GVHD, thrombocytopenia and anemia portended inferior survival and were used to develop a prognostic score for mortality from PGF. This analysis identifies risk factors predictive of PGF and poor survival in those without recovery.