Transcatheter closure of fenestrated atrial septal aneurysm: feasibility and long-term results. Issue 1 (January 2022)

• Record Type: Journal Article
• Authors: Mahmoud, Heba Talat; Gaio, Gianpiero; Giordano, Mario; Pizzuto, Alessandra; Cuman, Madgalena; Asklany, Hany Taha; Palladino, Maria Teresa; Russo, Maria Giovanna; Santoro, Giuseppe
• Is Part Of: Journal of cardiovascular medicine. Volume 23:Issue 1(2022)
• Publication Date: 2022-01
• Subjects: atrial septal aneurysm -- atrial septal defect -- device -- multifenestrated -- percutaneous -- transcatheter; Cardiology -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; Cardiology -- Periodicals; Cardiovascular Diseases -- Periodicals; 616.1005
• DOI: 10.2459/JCM.0000000000001239
• Languages: English
• ISSNs: 1558-2027

Abstract

Abstract : Aim: To report on the feasibility, efficacy and long-term outcome of transcatheter closure of fenestrated Atrial Septal Aneurysm (ASA). Methods: Between April 2000 and May 2020, 568 patients with fenestrated ASA underwent transcatheter closure at two large-volume Pediatric Cardiology and GUCH Units (Naples and Massa, Italy). Procedural indications were cardiac volume overload in 223 patients (39%) or prophylaxis of paradoxical embolization in 345 patients (61%). Patients' median age and weight were 42 years (range 19–52) and 66 kg (range 54–79), respectively. One-hundred and thirty-nine patients (25%) were younger than 18 years. Results: Single fenestration was found in 311 patients (55%) (Group 1), whereas 257 patients (45%) had multifenestrated ASA (Group 2). The procedure was successful in all but seven patients (1.2%). In Group 1, closure was achieved with a single device. In Group 2, one device was used in 168 patients (67%), two devices in 74 patients (28%), three devices in 12 patients (5%), and four devices in 1 patient (0.3%). The early complication rate was 3%, without any difference according to anatomy or patient's age. At discharge, complete shunt closure was higher in Group 1 (92% vs. 72%, P < 0.0001), without any difference between groups at the last follow-up evaluation (100% vs. 99%, P = 0.12). Procedural safety was persistent during the long-term follow-up (mean 7.2 ± 5.4, range 0–19 years): freedom from adverse events was 97% at 10–15 years. Seventeen patients (3%) were submitted to reintervention, mostly as prophylaxis of paradoxical embolization. Conclusion: Transcatheter closure of perforated ASA is technically feasible in a high percentage of cases, with excellent long-term outcomes. Abstract : Supplemental Digital Content is available in the text