Patients with amnesic mild cognitive impairment due to Alzheimer's disease and with epileptiform‐like signatures showed abnormal cortical sources of resting state delta EEG rhythms: An EEG study. (31st December 2021)

• Record Type: Journal Article
• Authors: Tucci, Federico; Babiloni, Claudio; Noce, Giuseppe; Di Bonaventura, Carlo; Lizio, Roberta; Lorenzo, Ivan; Soricelli, Andrea; Ferri, Raffaele; Nobili, Flavio; Famà, Francesco; Arnaldi, Dario; Palma, Eleonora; Cifelli, Pierangelo; Marizzoni, Moira; Stocchi, Fabrizio; Frisoni, Giovanni; Percio, Claudio Del
• Is Part Of: Alzheimer's & dementia. Volume 17(2021)Supplement 5
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-12-31
• Subjects: Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1002/alz.053827
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: Background: Cortical sources of resting state eyes‐closed electroencephalographic (rsEEG) rhythms are abnormal in patients with amnesic mild cognitive impairment due to Alzheimer's disease (ADMCI). In the present exploratory and retrospective study, we tested whether those abnormalities may be stronger in ADMCI with (ADMCI‐EEA) than without (ADMCI‐noEEA) epileptiform‐like EEG signatures. Method: Clinical, neurophysiological, and rsEEG data in 56 ADMCI patients and 35 normal elderly (Nold) subjects were available in a national archive. The eLORETA freeware estimated rsEEG cortical sources. Area under receiver operating characteristic (AUROC) curves indexed the accuracy of eLORETA solutions in the classification between ADMCI‐EEA and ADMCI‐noEEA individuals. Result: As compared to ADMCI‐noEEA patients, ADMCI‐EEA (N=25%) patients showed worse executive functions (Trail making Test B‐A) and more abnormalities in widespread delta (about 2‐4 Hz) and temporal theta (about 4‐6 Hz) source activities. Furthermore, those sources were able to classify with moderate/good accuracies (AUROC =0.75‐0.85) the ADMCI‐EEA vs. ADMCI‐noEEA individuals. Conclusion: These results suggest higher abnormalities in low‐frequency (i.e. delta and theta) rsEEG cortical activities in ADMCI‐EEA than ADMCI‐noEEA patients at both group and individual levels.