A Case of in utero Transmission of Drug-resistant HIV in the United States. Issue 1 (January 2022)

• Record Type: Journal Article
• Authors: Weyland, Cassie; Mirani, Gayatri; Gillespie, Susan L.; Paul, Mary E.
• Is Part Of: Pediatric infectious disease journal. Volume 41:Issue 1(2022)
• Publication Date: 2022-01
• Subjects: perinatal transmission -- HIV drug resistance -- antiretroviral therapy; Communicable diseases in children -- Periodicals; Infection in children -- Periodicals; 618.929
• DOI: 10.1097/INF.0000000000003329
• Languages: English
• ISSNs: 0891-3668

Abstract

Abstract : Thanks to the development of antiretroviral drugs and the implementation of routine perinatal prophylaxis, primarily containing zidovudine, modern-day rates of perinatal transmission of HIV are very low in developed countries. We present a case of perinatal transmission of HIV with extensive nucleoside reverse transcriptase inhibitor resistance as a reminder that perinatal transmission of resistance mutations can occur. This case calls for further investigation into the utility of using genotype to determine neonatal prophylaxis in the setting of maternal HIV drug resistance.