Transdural Skull Base Infiltration by Glioblastoma: Case Report and Review of the Literature. (25th January 2023)

• Record Type: Journal Article
• Authors: Thrull, Michael; Atasi, Khaled; Boese, Lennart-Maximilian; Cakar, Mahmut; Heller, Ullrich; Jansen, Nils; Menzel, Leoni-Christine; Omaimen, Hassan; Theis, Katharina; Karacic, Damir; Dimov, Diyan; Coras, Roland; Klingebiel, Randolf
• Other Names: Rapoport Abr o Academic Editor.
• Is Part Of: Case reports in otolaryngology. Volume 2023(2023)
• Publication Date: 2023-01-25
• Subjects: Otolaryngology -- Periodicals; Otolaryngology -- Case studies -- Periodicals; Otolaryngology; Otorhinolaryngologic Diseases; Otolaryngology; Periodicals; Case studies; Periodicals; Case Reports; Fulltext; Internet Resources; Periodicals; 617.51
• DOI: 10.1155/2023/4727288
• Languages: English
• ISSNs: 2090-6765

Abstract

Abstract : We report the rare occurrence of a temporal glioblastoma multiforme (GBM) showing transdural tumor extension into adjacent mastoid cells. As the dura mater provides a barrier to intraaxial tumors, GBM seldom penetrates into the skull base, even though it is a high-grade astrocytoma with a tendency to spread. Yet, some mechanisms of GBM-induced skull invasion have been identified, making this entity a very rare but nonetheless relevant differential diagnosis in otherwise ambiguous cases of an intracerebral tumor extending into the skull base. In addition, imaging markers that may assist in distinguishing extra- from intraaxial tumor infiltration of the temporal bone are described.