Obstructive and Nonobstructive Hypertrophic Cardiomyopathy: Differences in Global and Segmental Myocardial Strain by Cardiac Magnetic Resonance Feature Tracking. Issue 1 (January 2022)

• Record Type: Journal Article
• Authors: Palmisano, Vitanio; Cossa, Stefano; Esposito, Antonio; Bassareo, Pier P.; Porcu, Michele; Cau, Riccardo; Pontone, Gianluca; Suri, Jasjit S.; Saba, Luca
• Is Part Of: Journal of thoracic imaging. Volume 37:Issue 1(2022)
• Publication Date: 2022-01
• Subjects: hypertrophic cardiomyopathy -- ventricular outflow obstruction -- left ventricular function -- magnetic resonance imaging -- cardiac imaging techniques; Chest -- Radiography -- Periodicals; Chest -- Diseases -- Diagnosis -- Periodicals; 617.540757
• DOI: 10.1097/RTI.0000000000000612
• Languages: English
• ISSNs: 0883-5993

Abstract

Abstract : Purpose: To evaluate any significant differences in myocardial strain between hypertrophic obstructive cardiomyopathy (HOCM) and nonobstructive ones (HNCM), as assessed by cardiac magnetic resonance feature tracking (CMR-FT). Materials and Methods: A total of 17 patients (mean age: 54±14 y) with echocardiographic diagnosis of HOCM (left ventricular outflow tract obstruction peak gradient ≥30 mm Hg), 19 patients (mean age: 49±16 y) with HNCM (peak gradient <30 mm Hg), and 18 age-matched and gender-matched healthy controls (mean age: 42±14 y). All patients underwent cardiac MRI with SSFP-cine to assess left ventricular global and segmental strain analysis by CMR-FT. Late gadolinium enhancement (LGE) sequences were used for semiautomatic quantification of LGE volume, mass, and percentage. Results: The magnitude of global radial, circumferential, and longitudinal strain as well as strain rate were significantly lower in all patients in comparison to controls ( P <0.001), except for radial and circumferential strain between HOCM and controls ( P =0.270; P =0.154). The latter strain parameters were significantly higher in HOCM than HNCM (radial strain: 31.67±7.55 vs. 21.26±7.10, P <0.001; circumferential strain: −17.94±2.78 vs. −13.46±3.42, P <0.001). Radial and circumferential strain and circumferential diastolic strain rate were higher in mid-anterior ( P <0.001), mid-anteroseptal ( P <0.001), and all apical segments ( P <0.005) between the 2 groups of patients. Moreover, longitudinal strain was higher only in apical segments in HOCM ( P <0.02). Conclusions: HOCM patients showed higher left ventricular apical, mid-anterior, and mid-anteroseptal strain parameters compared with HNCM. These differences were independent of corresponding segmental thickness and LGE amount. Abstract : Supplemental Digital Content is available in the text.