Overweight and Obesity Are Increased in Childhood-Onset Cerebrovascular Disease. (April 2013)

• Record Type: Journal Article
• Authors: Pearson, Virginia; Ruzas, Chris; Krebs, Nancy F.; Goldenberg, Neil A.; Manco-Johnson, Marilyn J.; Bernard, Timothy J.
• Is Part Of: Journal of child neurology. Volume 28:Number 4(2013)
• Page Start: 517
• Page End: 519
• Publication Date: 2013-04
• Subjects: obesity -- arterial ischemic -- stroke -- cerebral sinovenous thrombosis -- overweight; Nervous system -- Diseases -- Periodicals; 618.928
• DOI: 10.1177/0883073812446160
• Languages: English
• ISSNs: 0883-0738

Abstract

The objective of this work was to determine whether overweight/obesity is a risk factor for cerebrovascular disease in children. The study included 53 children with non–neonatal-onset cerebral sinovenous thrombosis or arterial ischemic stroke. The prevalence of overweight/obesity was compared between this cohort and healthy children from the National Health and Nutrition Examination Survey. In addition, cerebral sinovenous thrombosis patients were compared to a group of matched hospitalized controls. The prevalence of overweight/obesity was significantly higher in the cerebral sinovenous thrombosis cohort (55%), but not the arterial ischemic stroke cohort (36%), relative to national controls (32%; P = .04 and P = .81, respectively). Similarly, the prevalence of overweight/obesity was significantly higher in the cerebral sinovenous thrombosis cohort than in Colorado controls (25%; P = .02). In conclusion, the prevalence of overweight/obese was significantly increased in cerebral sinovenous thrombosis patients as compared to both national and local controls. Results should be evaluated in a larger multi-institutional cohort.