Application of Machine Learning for Tumor Growth Inhibition – Overall Survival Modeling Platform. (13th December 2020)

• Record Type: Journal Article
• Authors: Chan, Phyllis; Zhou, Xiaofei; Wang, Nina; Liu, Qi; Bruno, René; Jin, Jin Y.
• Is Part Of: CPT: pharmacometrics & systems pharmacology. Volume 10:Number 1(2021)
• Page Start: 59
• Page End: 66
• Publication Date: 2020-12-13
• Subjects: Pharmacokinetics -- Periodicals; Pharmacology -- Periodicals; Pharmacokinetics; Periodicals; 615.05
• DOI: 10.1002/psp4.12576
• Languages: English
• ISSNs: 2163-8306

Abstract

Abstract : Machine learning (ML) was used to leverage tumor growth inhibition (TGI) metrics to characterize the relationship with overall survival (OS) as a novel approach and to compare with traditional TGI‐OS modeling methods. Historical dataset from a phase III non‐small cell lung cancer study (OAK, atezolizumab vs. docetaxel, N = 668) was used. ML methods support the validity of TGI metrics in predicting OS. With lasso, the best model with TGI metrics outperforms the best model without TGI metrics. Boosting was the best linear ML method for this dataset with reduced estimation bias and lowest Brier score, suggesting better prediction accuracy. Random forest did not outperform linear ML methods despite hyperparameter optimization. Kernel machine was marginally the best nonlinear ML method for this dataset and uncovered nonlinear and interaction effects. Nonlinear ML may improve prediction by capturing nonlinear effects and covariate interactions, but its predictive performance and value need further evaluation with larger datasets.