Synthesis of Diverse Heterocyclic Scaffolds by (3+3) and (3+4) Cycloannulations of Donor‐Acceptor Vinylcyclopropanes. Issue 1 (18th October 2021)

• Record Type: Journal Article
• Authors: Faltracco, Matteo; Strähler, Sebastian; Snabilié, Demi; Ruijter, Eelco
• Is Part Of: Advanced synthesis & catalysis. Volume 364:Issue 1(2022)
• Page Start: 53
• Page End: 57
• Publication Date: 2021-10-18
• Subjects: Vinylcyclopropanes -- Cascade reactions -- Palladium catalysis -- (3+3) cycloannulation -- (3+4) cycloannulation; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202101063
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: Palladium‐catalyzed (3+3) and (3+4) cycloannulations between vinylcyclopropanes and various (hetero)aromatic aldehydes are reported. The use of phosphonate‐substituted vinylcyclopropanes provides access to a variety of bi‐ or tricyclic heteroaromatic scaffolds via an allylation/olefination cascade. The nature of the mechanism was investigated by various control experiments. Abstract :