Signaling, metabolism, and cancer: An important relationship for therapeutic intervention. Issue 8 (12th February 2021)

• Record Type: Journal Article
• Authors: Vaghari‐Tabari, Mostafa; Ferns, Gordon A.; Qujeq, Durdi; Andevari, Ali Nosrati; Sabahi, Zahra; Moein, Soheila
• Is Part Of: Journal of cellular physiology. Volume 236:Issue 8(2021)
• Page Start: 5512
• Page End: 5532
• Publication Date: 2021-02-12
• Subjects: cancer -- cancer treatment -- metabolism -- signaling pathways; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.30276
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract: In cancerous cells, significant changes occur in the activity of signaling pathways affecting a wide range of cellular activities ranging from growth and proliferation to apoptosis, invasiveness, and metastasis. Extensive changes also happen with respect to the metabolism of a cancerous cell encompassing a wide range of functions that include: nutrient acquisition, biosynthesis of macromolecules, and energy generation. These changes are important and some therapeutic approaches for treating cancers have focused on targeting the metabolism of cancerous cells. Oncogenes and tumor suppressor genes have a significant effect on the metabolism of cells. There appears to be a close interaction between metabolism and the signaling pathways in a cancerous cell, in which the interaction provides the metabolic needs of a cancerous cell for uncontrolled proliferation, resistance to apoptosis, and metastasis. In this review, we have reviewed the latest findings in this regard and briefly review the most recent research findings regarding targeting the metabolism of cancer cells as a therapeutic approach for treatment of cancer. Abstract : Various studies have shown that metabolism is reprogrammed in cancer cells, and this reprogramming which mediated by signaling pathways is in line with meeting the metabolic needs of cancer cells for growth, proliferation, survival, invasion, and metastasis. Antitumor compounds that have the ability to target both metabolism and signaling may be helpful in the treatment of cancer.