A Decade of Advances in Single‐Cell Nanocoating for Mammalian Cells. Issue 13 (23rd April 2021)

• Record Type: Journal Article
• Authors: Lee, Hojae; Kim, Nayoung; Rheem, Hyeong Bin; Kim, Beom Jin; Park, Ji Hun; Choi, Insung S.
• Is Part Of: Advanced healthcare materials. Volume 10:Issue 13(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-04-23
• Subjects: cell‐surface engineering -- cytoprotection -- mammalian cells -- nanocoating -- single‐cell nanoencapsulation; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202100347
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: Strategic advances in the single‐cell nanocoating of mammalian cells have noticeably been made during the last decade, and many potential applications have been demonstrated. Various cell‐coating strategies have been proposed via adaptation of reported methods in the surface sciences and/or materials identification that ensure the sustainability of labile mammalian cells during chemical manipulation. Here an overview of the methodological development and potential applications to the healthcare sector in the nanocoating of mammalian cells made during the last decade is provided. The materials used for the nanocoating are categorized into polymers, hydrogels, polyphenolic compounds, nanoparticles, and minerals, and the corresponding strategies are described under the given set of materials. It also suggests, as a future direction, the creation of the cytospace system that is hierarchically composed of the physically separated but mutually interacting cellular hybrids. Abstract : During the last decade, significant advances have been made in single‐cell nanocoating of mammalian cells, in which individual mammalian cells are protected by the mechanically and physicochemically robust nanocoats. The cell‐in‐shell structures promise potential applications to the healthcare sectors as well as providing a research platform for the chemical manipulation of cellular fate at the single‐cell level.