All-in-one CoFe2O4@Tf nanoagent with GSH depletion and tumor-targeted ability for mutually enhanced chemodynamic/photothermal synergistic therapy. (1st December 2022)

• Record Type: Journal Article
• Authors: Chen, Niping; Wang, Yakun; Zeng, Yaoxun; Li, Yushan; Pan, Zhenxing; Li, Haihong; Chen, Jingman; Chen, Zefeng; Yuan, Jiongpeng; Yan, Wen; Lu, Yu-Jing; Liu, Xujie; He, Yan; Zhang, Kun
• Is Part Of: Biomaterials science. Volume 11:Number 3(2023)
• Page Start: 828
• Page End: 839
• Publication Date: 2022-12-01
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1039/d2bm01542k
• Languages: English
• ISSNs: 2047-4830

Abstract

Abstract : Fabrication process of CFOT and schematic illustration mechanism of CFOT for PTT/CDT synergistic therapy with GSH depletion and tumor targeting. Abstract : In the complex and severe tumor microenvironment, the antitumor efficiency of nanomedicines is significantly limited by their low-efficacy monotherapy, non-tumor targeting, and systemic toxicity. Herein, to achieve tumor-targeted and enhanced chemodynamic/photothermal therapy (CDT/PTT), we fabricated an "all-in-one" biocompatible transferrin-loaded cobalt ferrate nanoparticle (CoFe2 O4 @Tf (CFOT)) with multiple functions by a simple solvothermal method and the following transferrin (Tf) functionalization. Upon exposure to 808 nm laser irradiation, CFOT, as a novel photothermal agent, exhibited outstanding phototherapeutic activity because of its excellent photothermal conversion efficiency ( η = 46.5%) for high-performance PTT. Moreover, CFOT with multiple redox pairs could efficiently convert endogenous H2 O2 to hazardous hydroxyl radicals (˙OH) via Fenton reactions while scavenging overexpressed GSH in the tumor microenvironment to realize self-reinforcing CDT. Importantly, CFOT undergoes a promoted Fenton-type reaction upon increasing the temperature under a photothermal effect and could augment PTT by high-level ˙OH, exhibiting a considerably enhanced synergistic therapeutic effect. In vitro and in vivo experimental results demonstrated that CFOT has good potential as an "all-in-one" nanoagent to combine photothermal, chemodynamic, and tumor targeting for efficient tumor elimination.