Chemical composition, antifungal and antiproliferative activities of essential oils from Thymus numidicus L. Issue 24 (17th December 2021)

• Record Type: Journal Article
• Authors: Elaissi, Ameur; Elsharkawy, Eman; El Mokni, Ridha; Debbabi, Haïfa; Brighenti, Virginia; Nardoni, Simona; Pellati, Federica; Hammami, Saoussen
• Is Part Of: Natural product research. Volume 35:Issue 24(2021)
• Page Start: 5888
• Page End: 5893
• Publication Date: 2021-12-17
• Subjects: Thymus numidicus -- essential oil -- chemical composition -- antifungal activity -- antiproliferative effect; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1800697
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: In this study, Thymus numidicus Poir. plant material was collected from two different locations in north-western Tunisia and the aerial parts essential oils (EOs) were extracted via hydro-distillation. Gas chromatography coupled to mass spectrometry (GC-MS) and flame ionisation detection (GC-FID) were used for the qualitative analysis and quantification of the volatile constituents. Thymol (50.1–52.8%) was identified as the main compound of both EOs. To evaluate the potential application of the EOs as antifungal agents, the in vitro inhibitory effects were tested against six fungal strains; a strong antifungal activity of one sample was observed (MIC = 40–400 µg/mL). The in vitro antiproliferative activity was investigated on two human cancer cell lines, i.e. the colonic (HCT116) and breast adenocarcinoma (MCF7) using the colourimetric MTT assay. Again, the same sample demonstrated to possess good antiproliferative activity against both cancer cell lines, with IC50 values of 26.9 and 11.7 µg/mL, respectively. Abstract : UF0001