Antibacterial natural products lobophorin L and M from the marine-derived Streptomyces sp. 4506. Issue 24 (17th December 2021)

• Record Type: Journal Article
• Authors: Luo, Minghe; Tang, Lingjie; Dong, Yulu; Huang, Hongbo; Deng, Zixin; Sun, Yuhui
• Is Part Of: Natural product research. Volume 35:Issue 24(2021)
• Page Start: 5581
• Page End: 5587
• Publication Date: 2021-12-17
• Subjects: Lobophorin L and M -- marine Streptomyces -- antibacterial activity -- ansamycin derivatives; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1797730
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Two new spirotetronate natural products, lobophorin L (1 ) and lobophorin M (2 ), together with three known lobophorin-like spirotetronate antibiotics (3 –5 ) and two known ansamycins (6 –7 ), were isolated from the marine-derived Streptomyces sp. 4506. The structures of 1 and 2 were established on the basis of HRESIMS as well as 1D and 2D NMR datasets. Antibacterial assay showed that, compounds 1 and 3 –5 exhibited strong to moderate antibacterial activities against Micrococcus luteus and Bacillus thuringiensis with MIC values ranging from 0.0625 to 8 μg/mL, while compounds 3 and 6 showed weak antibacterial activities against Staphylococcus aureus and MRSA. The antibacterial activities of the lobophorins in this study indicated that the more substitution number of the sugar moieties at C-9 of the lobophorin, the stronger antimicrobial properties it may deserve, and the higher the oxidation degree of substituent group at C-3D, the better antibacterial activities of its corresponding compound could be. Graphical Abstract: UF0001