Demographic and clinical features of critically ill patients with COVID-19 in Greece: The burden of diabetes and obesity. (August 2020)

• Record Type: Journal Article
• Authors: Halvatsiotis, P.; Kotanidou, A.; Tzannis, K.; Jahaj, E.; Magira, E.; Theodorakopoulou, M.; Konstandopoulou, G.; Gkeka, E.; Pourzitaki, C.; Kapravelos, N.; Papoti, S.; Sileli, M.; Gogos, C.; Velissaris, D.; Markou, N.; Stefanatou, E.; Vlachogianni, G.; Aimoniotou, E.; Komnos, A.; Zafeiridis, T.; Koulouvaris, P.; Armaganidis, A.; Bamias, A.; Dimopoulos, G.
• Is Part Of: Diabetes research and clinical practice. Volume 166(2020)
• Publication Date: 2020-08
• Subjects: Greece -- Type-2 diabetes -- Obesity -- Covid-19 -- Intensive Care Unit -- Critically ill; Diabetes -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462
• DOI: 10.1016/j.diabres.2020.108331
• Languages: English
• ISSNs: 0168-8227

Abstract

Highlights: Critically ill Covid-19 patients with type-2 diabetes show decreased survival rate. Obese critically ill Covid-19 pneumonia patients are more often of younger age. Non-obese Covid-19 pneumonia survivors are older than obese survivors. Age and cardiovascular disease in Covid-19 patients are not related to early death. Abstract: Aims: The aim of the study was to investigate the association between type-2 diabetes mellitus, other underlying diseases and obesity with the outcomes of critically ill Covid-19 patients in Greece. Methods: In this retrospective observational multi-centre study, data and outcomes of 90 RNA 2109-nCoV confirmed critically ill patients from 8 hospitals throughout Greece, were analysed. All reported information stand through April 13th 2020. Results: The median age of the patients was 65.5 (IQR 56–73), majority were male (80%) and obesity was present in 34.4% of patients most prevalent to younger than 55 years. Hypertension was the prevailing comorbidity (50%), followed by cardiovascular diseases (21.1%) and type-2 diabetes (18.9%). At admission, common symptoms duration had a median of 8 (IQR 5–11) days. A 13.3% of the patients were discharged, 53.4% were still in the ICUs and 28.9% deceased who were hospitalised for fewer days than the survivors [6 (IQR 3–9) vs. 9 (IQR 7–14.5) respectively]. Aging was not a risk factor but diabetes deteriorates the outcomes. Obesity poses a suggestive burden as it was more notable in deceased versus survivors. Conclusions: Type 2 diabetes and obesity may have contributed to disease severity and mortality in COVID-19 critically ill patients in Greece.