Gut microbiome and neurosurgery: Implications for treatment. Issue 4 (10th October 2022)

• Record Type: Journal Article
• Authors: Willman, Jonathan; Willman, Matthew; Reddy, Ramya; Fusco, Anna; Sriram, Sai; Mehkri, Yusuf; Charles, Jude; Goeckeritz, Joel; Lucke‐Wold, Brandon
• Is Part Of: Clinical and translational discovery. Volume 2:Issue 4(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-10-10
• Subjects: faecal transplant -- microbiome -- neurosurgery -- probiotics; Medicine -- Periodicals; Medicine; Periodicals; 616
• DOI: 10.1002/ctd2.139
• Languages: English
• ISSNs: 2768-0622

Abstract

Abstract: Introduction: The aim of this review is to summarize the current understanding of the gut‐brain axis (GBA), its impact on neurosurgery, and its implications for future treatment. Background: An abundance of research has established the existence of a collection of pathways between the gut microbiome and the central nervous system (CNS), commonly known as the GBA. Complicating this relationship, the gut microbiome bacterial diversity appears to change with age, antibiotic exposure and a number of external and internal factors. Methods: In this paper, we present the current understanding of the key protective and deleterious roles the gut microbiome plays in the pathogenesis of several common neurosurgical concerns. Results: Specifically, we examine how spinal cord injury, traumatic brain injury and stroke may cause gut microbial dysbiosis. Furthermore, this link appears to be bidirectional as gut dysbiosis contributes to secondary CNS injury in each of these ailment settings. This toxic cycle may be broken, and the future secondary damage rescued by timely, therapeutic, gut microbiome modification. In addition, a robust gut microbiome appears to improve outcomes in brain tumour treatment. There are several primary routes by which microbiome dysbiosis may be ameliorated, including faecal microbiota transplant, oral probiotics, bacteriophages, genetic modification of gut microbiota and vagus nerve stimulation. Conclusion: The GBA represents an important component of patient care in the field of neurosurgery. Future research may illuminate ideal methods of therapeutic microbiome modulation in distinct pathogenic settings. Abstract : There is a strong bidirectional link between gut microbiome dysbiosis and worsening secondary injury post‐stroke, SCI, and TBI.These deficits may be rescued by timely rejuvenation of the gut microbiome. The maintenance of a healthy microbiome plays a protective role in the setting of tumor chemotherapy and immunotherapy. The future of gut microbiome modulation for neurosurgical therapeutic goals appears increasingly promising.