Research journey of respirasome. Issue 5 (9th January 2020)

• Record Type: Journal Article
• Authors: Wu, Meng; Gu, Jinke; Zong, Shuai; Guo, Runyu; Liu, Tianya; Yang, Maojun
• Is Part Of: Protein & cell. Volume 11:Issue 5(2020)
• Page Start: 318
• Page End: 338
• Publication Date: 2020-01-09
• Subjects: electron transport chain -- supercomplex organization -- cellular respiration -- structure of respirasome -- cryo-EM -- megacomplex; Proteins -- Periodicals; Cells -- Periodicals; Cytology -- Periodicals; 572.6
• DOI: 10.1007/s13238-019-00681-x
• Languages: English
• ISSNs: 1674-800X

Abstract

Abstract: Respirasome, as a vital part of the oxidative phosphorylation system, undertakes the task of transferring electrons from the electron donors to oxygen and produces a proton concentration gradient across the inner mitochondrial membrane through the coupled translocation of protons. Copious research has been carried out on this lynchpin of respiration. From the discovery of individual respiratory complexes to the report of the high-resolution structure of mammalian respiratory supercomplex I1 III2 IV1, scientists have gradually uncovered the mysterious veil of the electron transport chain (ETC). With the discovery of the mammalian respiratory mega complex I2 III2 IV2, a new perspective emerges in the research field of the ETC. Behind these advances glitters the light of the revolution in both theory and technology. Here, we give a short review about how scientists 'see' the structure and the mechanism of respirasome from the macroscopic scale to the atomic scale during the past decades.