MicroRNA‐141 promotes the proliferation of non‐small cell lung cancer cells by regulating expression of PHLPP1 and PHLPP2. Issue 17 (16th June 2014)

• Record Type: Journal Article
• Authors: Mei, Zhoufang; He, Yanchao; Feng, Jingjing; Shi, Jindong; Du, Yong; Qian, Ling; Huang, Qihui; Jie, Zhijun
• Is Part Of: FEBS letters. Volume 588:Issue 17(2014)
• Page Start: 3055
• Page End: 3061
• Publication Date: 2014-06-16
• Subjects: MicroRNA-141 -- PH domain leucine-rich-repeats protein phosphatase 1 -- PH domain leucine-rich-repeats protein phosphatase 2 -- Non-small cell lung cancer -- Proliferation; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1016/j.febslet.2014.06.020
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : The dysregulation of microRNAs (miRNAs) is crucially implicated in the development of various cancers. In this study, we explored the biological role of miR‐141 in non‐small cell lung cancer (NSCLC). miR‐141 expression was significantly up‐regulated in NSCLC tissues, and its overexpression accelerated NSCLC cell proliferation in vitro and tumor growth in vivo. We subsequently identified the antagonists of PI3K/AKT signaling, PH domain leucine‐rich‐repeats protein phosphatase 1 (PHLPP1) and PHLPP2, as direct targets of miR‐141. Re‐introduction of PHLPP1 and PHLPP2 abrogated miR‐141‐induced proliferation of NSCLC cells. Together, the results of this study suggest that miR‐141 and its targets PHLPP1 and PHLPP2 play critical roles in NSCLC tumorigenesis, and provide potential therapeutic targets for NSCLC treatment. Abstract : miR‐141 is up‐regulated in NSCLC tissues. miR‐141 promotes proliferation of NSCLC cells in vitro. miR‐141 promotes NSCLC tumor growth in vivo. miR‐141 directly targets PHLPP1 and PHLPP2. Repression of PHLPP1 and PHLPP2 plays crucial roles in miR‐141‐induced proliferation of NSCLC cells.