Association between TLR2 Arg677Trp polymorphism and tuberculosis susceptibility: A meta-analysis. (July 2020)

• Record Type: Journal Article
• Authors: Jin, Xiaochun; Yin, Shuzhou; Zhang, Youtao; Chen, Xu
• Is Part Of: Microbial pathogenesis. Volume 144(2020)
• Publication Date: 2020-07
• Subjects: Tuberculosis -- Toll-like receptor 2 -- Polymorphism -- Meta-analysis; TB Tuberculosis -- TLRs Toll-like receptors -- PRRs pathogen recognizing receptors -- PB Population-based -- HWE Hardy-Weinberg equilibrium -- RFLP Restricted Fragment Length Polymorphism -- CI Confidence interval -- OR Odds ratio -- SNP Single nucleotide polymorphism; Pathogenic microorganisms -- Periodicals; Pathology, Molecular -- Periodicals; Communicable Diseases -- microbiology -- Periodicals; Communicable Diseases -- parasitology -- Periodicals; Micro-organismes pathogènes -- Périodiques; Pathologie moléculaire -- Périodiques; Electronic journals; 616.9041
• DOI: 10.1016/j.micpath.2020.104173
• Languages: English
• ISSNs: 0882-4010

Abstract

Abstract: Background: Toll-like receptor 2 (TLR2) is an important member of TLRs, which is significant in the initial of inflammatory response against bacteria. Several studies have been conducted to investigate the TLR2 Arg677Trp polymorphism and Tuberculosis (TB) susceptibility. Unfortunately, the results of previous studies were inconsistent. Objectives: The aim of present study was to investigate the relationship between TLR2 Arg677Trp polymorphisms and TB susceptibility. Methods: The association between the TLR2 Arg677Trp polymorphism and TB susceptibility was assessed by odds ratios (OR) together with their 95% confidence intervals (95%CI). Results: Six case-control studies were enrolled in the meta-analysis. Overall, significant association between TLR2 Arg677Trp polymorphism and TB risk were found neither under allele contrast (C vs. T: OR = 0.59, 95%CI = 0.28–1.23, P = 0.158) nor under recessive genetic model (CC vs. CT/TT: OR = 0.43, 95%CI = 0.12–1.51, P = 0.188). Conclusion: We conclude that TLR2 Arg677Trp polymorphism is not associated with TB susceptibility. Highlights: TLR2 Arg677Trp polymorphism is not associated with TB susceptibility. Meta-analysis is an excellent statistics instrument which enhances the statistics efficiency. This is the first meta-analysis of TLR2 Arg677Trp polymorphism with TB risk.