Gastric Hyperplastic Polyps Can Shrink After Discontinuation of Proton Pump Inhibitors: A Case Series Compared With Continuation of Proton Pump Inhibitors. Issue 3 (8th March 2022)

• Record Type: Journal Article
• Authors: Nikaido, Mitsuhiro; Miyamoto, Shin'ichi; Utsumi, Takahiro; Shimizu, Takahiro; Nakanishi, Yuki; Kumagai, Ken; Teramura, Mari; Setoyama, Takeshi; Seno, Hiroshi
• Is Part Of: Journal of clinical gastroenterology. Volume 56:Issue 3(2022)
• Page Start: e216
• Page End: e221
• Publication Date: 2022-03-08
• Subjects: hyperplastic polyp -- proton pump inhibitor -- shrinkage -- anemia; Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; Gastroenterology -- Periodicals; Digestive organs -- Diseases; Gastroenterology; Periodicals; Periodicals; 616.33005
• DOI: 10.1097/MCG.0000000000001577
• Languages: English
• ISSNs: 0192-0790

Abstract

Abstract : Goal: This study investigated whether gastric hyperplastic polyps (GHPs) shrink after discontinuation of proton pump inhibitor (PPI) alone. Background: Long-term use of PPIs has been reported to increase the incidence of GHPs, which sometimes bleed and cause anemia. We experienced a patient whose recurrent hemorrhagic GHPs associated with long-term use of PPIs had disappeared after discontinuation of PPIs. Study: This study was conducted retrospectively at Kyoto University Hospital. Patients with histologically confirmed GHPs who had been taking PPIs for >6 months and who had undergone a repeat endoscopy within 2 years were included. Polyp shrinkage was defined as the disappearance of polyps or a reduction of >50% in the long diameter of the largest polyp. Results: Six patients who discontinued PPIs were compared with 17 patients who continued PPIs. Polyp shrinkage was significantly more frequent in the PPI-discontinuation group (5/6, 83%) than in the PPI continuation group (0/17, 0%) ( P <0.001). In 2 patients in the PPI-discontinuation group, the polyps completely disappeared finally. Conclusion: These findings suggest that discontinuation of PPIs can shrink GHPs in patients using PPIs.