Bioactive compounds derived from the marine-derived fungus MCCC3A00951 and their influenza neuraminidase inhibition activity in vitro and in silico. Issue 24 (17th December 2021)

• Record Type: Journal Article
• Authors: Liu, Shun-Zhi; He, Feng-Ming; Bin, Yan-lin; Li, Chu-Fang; Xie, Bao-Ying; Tang, Xi-Xiang; Qiu, Ying-Kun
• Is Part Of: Natural product research. Volume 35:Issue 24(2021)
• Page Start: 5621
• Page End: 5628
• Publication Date: 2021-12-17
• Subjects: Anti-influenza neuraminidase activity -- cyclopenin -- mangrove fungus -- molecular docking -- Penicillium polonicum MCCC3A00951; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1817015
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Penicillium polonicum MCCC3A00951 is a fungus with influenza neuraminidase (NA) inhibition activity derived from a sediment of the mangrove forest of Zhangjiangkou in Fujian province, China. Chemical investigation on an ethyl acetate extract of its fermentation led to the isolation of a new compound, 7-hydroxy-3, 10-dehydrocyclopeptine (1 ), and 13 known compounds (2–14 ). The new compound was comprehensively characterised by high-resolution electrospray ionisation-mass spectrometry, and 1D, 2D nuclear magnetic resonance (NMR) spectra. The anti-influenza NA assay was performed to evaluate the potential biological activity. Surprisingly, Cyclopenin (2 ) showed potent influenza NA inhibition with an IC50 value of 5.02 μM. Besides, molecular docking simulation was performed to investigate the binding model of cyclopenin (2 ) with influenza NA. Consequently, cyclopenin (2 ) could be further optimised to be a potential anti-influenza NA candidate. Graphical Abstract: UF0001