Phytochemical analysis of Viburnum davidii Franch. and cholinesterase inhibitory activity of its dihydrochalcones. Issue 24 (17th December 2021)

• Record Type: Journal Article
• Authors: Tomassini, Lamberto; Ventrone, Antonio; Frezza, Claudio; Fabbri, Anna Maria; Fortuna, Stefano; Volpe, Maria Teresa; Cometa, Maria Francesca
• Is Part Of: Natural product research. Volume 35:Issue 24(2021)
• Page Start: 5794
• Page End: 5800
• Publication Date: 2021-12-17
• Subjects: Viburnum davidii Franch -- adoxaceae -- phytochemical analysis -- dihydrochalcones -- acetylcholinesterase inhibitory activity -- butyrylcholinesterase inhibitory activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1837814
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: One flavonoid (quercetin, 1 ) and three dihydrochalcones (6''- O - p -hydroxybenzoyl-davidioside, 2, 4'- O -methyl-davidioside, 3, and davidioside, 4 ) were isolated from the leaves and young branches of Viburnum davidii Franch. All the structures were identified by comparison of their spectroscopic data (NMR and MS) with those present in literature. In addition, compounds 2–4 were evaluated for their cholinesterase inhibitory (ChEI) activity, for the first time. Accordingly, compounds 2 and 4 showed significant inhibition of both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50 values equal to 36.883 and 39.274 µM, respectively for the former and 39.504 and 43.101 µM, respectively for the latter. Graphical Abstract: UF0001