Bacosides enrichment does not improve the anti-amnesic effect of Bacopa monnieri: behavioural and biochemical evidences. Issue 24 (17th December 2021)

• Record Type: Journal Article
• Authors: Arora, Renu; Kumar, Ritesh; Agarwal, Amit; Gupta, Y. K.
• Is Part Of: Natural product research. Volume 35:Issue 24(2021)
• Page Start: 6054
• Page End: 6057
• Publication Date: 2021-12-17
• Subjects: Amnesia -- Bacopa monnieri -- bacosides enriched fraction -- bacosides free fraction -- free radicals -- scopolamine; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1817919
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Bacopa monnieri (L.) Wettst. (BM) has been traditionally used in Ayurveda for improving memory and cognitive deficits which is also evidenced through experimental and clinical studies. The neuropharmacological properties of BM are attributed to "bacosides", a complex mixture of saponin compounds. BM extracts enriched with bacosides offers commercial advantage due to perceived higher efficacy. However, there is no scientific data to support the same. In the present study, methanolic extract of BM (BME) was compared with bacosides enriched (BME-EF) vis a vis bacosides free fraction (BME-FF). Potential antioxidant and cholinesterase inhibitory activity has been evaluated using in vitro and in vivo methods. BME showed not only the highest anti-amnesic efficacy but also antioxidant and cholinesterase inhibitory activity, followed by either BME-FF or BME-EF. Interestingly, no significant differences were found in between the groups. These findings dispel the notion that bacosides enrichment enhances anti-amnesic efficacy and also suggests the contribution of other components. Graphical Abstract: UF0001