Nerve growth factor (NGF) and NGF receptors in mesenchymal stem/stromal cells: Impact on potential therapies. (15th February 2021)

• Record Type: Journal Article
• Authors: Zha, Kangkang; Yang, Yu; Tian, Guangzhao; Sun, Zhiqiang; Yang, Zhen; Li, Xu; Sui, Xiang; Liu, Shuyun; Zhao, Jinmin; Guo, Quanyi
• Is Part Of: Stem cells translational medicine. Volume 10:Number 7(2021)
• Page Start: 1008
• Page End: 1020
• Publication Date: 2021-02-15
• Subjects: cellular therapy -- mesenchymal stem/stromal cell -- nerve growth factor -- P75NTR -- TrkA; Stem cells -- Periodicals; Regenerative medicine -- Periodicals; Periodicals; 616.0277405
• DOI: 10.1002/sctm.20-0290
• Languages: English
• ISSNs: 2157-6564

Abstract

Abstract: Mesenchymal stem/stromal cells (MSCs) are promising for the treatment of degenerative diseases and traumatic injuries. However, MSC engraftment is not always successful and requires a strong comprehension of the cytokines and their receptors that mediate the biological behaviors of MSCs. The effects of nerve growth factor (NGF) and its two receptors, TrkA and p75NTR, on neural cells are well studied. Increasing evidence shows that NGF, TrkA, and p75NTR are also involved in various aspects of MSC function, including their survival, growth, differentiation, and angiogenesis. The regulatory effect of NGF on MSCs is thought to be achieved mainly through its binding to TrkA. p75NTR, another receptor of NGF, is regarded as a novel surface marker of MSCs. This review provides an overview of advances in understanding the roles of NGF and its receptors in MSCs as well as the effects of MSC-derived NGF on other cell types, which will provide new insight for the optimization of MSC-based therapy. Abstract : In this study, the modulatory effect of exogenous nerve growth factor (NGF) on mesenchymal stem/stromal cell (MSC) functions and the paracrine effects of MSC-derived NGF on other cell types are discussed. In particular, the cytological functions and superiority of p75NTR+ MSCs as the basis for utilizing p75NTR as a surface marker to identify MSCs is presented.