Neural cell adhesion molecule regulates chondrocyte hypertrophy in chondrogenic differentiation and experimental osteoarthritis. (19th November 2019)

• Record Type: Journal Article
• Authors: Cheng, Bin-Feng; Lian, Jun-Jiang; Yang, Hai-Jie; Wang, Lei; Yu, Hao-Heng; Bi, Jia-Jia; Gao, Yao-Xin; Chen, Su-Juan; Wang, Mian; Feng, Zhi-Wei
• Is Part Of: Stem cells translational medicine. Volume 9:Number 2(2020)
• Page Start: 273
• Page End: 283
• Publication Date: 2019-11-19
• Subjects: chondrocyte differentiation -- chondrocyte hypertrophy -- mesenchymal stem cells -- NCAM -- osteoarthritis; Stem cells -- Periodicals; Regenerative medicine -- Periodicals; Periodicals; 616.0277405
• DOI: 10.1002/sctm.19-0190
• Languages: English
• ISSNs: 2157-6564

Abstract

Abstract: Chondrocyte hypertrophy-like change is an important pathological process of osteoarthritis (OA), but the mechanism remains largely unknown. Neural cell adhesion molecule (NCAM) is highly expressed and involved in the chondrocyte differentiation of mesenchymal stem cells (MSCs). In this study, we found that NCAM deficiency accelerates chondrocyte hypertrophy in articular cartilage and growth plate of OA mice. NCAM deficiency leads to hypertrophic chondrocyte differentiation in both murine MSCs and chondrogenic cells, in which extracellular signal-regulated kinase (ERK) signaling plays an important role. Moreover, NCAM expression is downregulated in an interleukin-1β-stimulated OA cellular model and monosodium iodoacetate-induced OA rats. Overexpression of NCAM substantially inhibits hypertrophic differentiation in the OA cellular model. In conclusion, NCAM could inhibit hypertrophic chondrocyte differentiation of MSCs by inhibiting ERK signaling and reduce chondrocyte hypertrophy in experimental OA model, suggesting the potential utility of NCAM as a novel therapeutic target for alleviating chondrocyte hypertrophy of OA. : Abstract : NCAM deficiency enhances hypertrophic chondrocyte differentiation of MSCs by increasing ERK signaling, and accelerates chondrocyte hypertrophy in experimental osteoarthritis.