Human mesenchymal stromal cells and derived extracellular vesicles: Translational strategies to increase their proangiogenic potential for the treatment of cardiovascular disease. (5th August 2020)

• Record Type: Journal Article
• Authors: Nazari-Shafti, Timo Z.; Neuber, Sebastian; Garcia Duran, Ana; Xu, Zhiyi; Beltsios, Eleftherios; Seifert, Martina; Falk, Volkmar; Stamm, Christof
• Is Part Of: Stem cells translational medicine. Volume 9:Number 12(2020)
• Page Start: 1558
• Page End: 1569
• Publication Date: 2020-08-05
• Subjects: angiogenesis -- cardiovascular disease -- extracellular vesicles -- mesenchymal stromal cells -- treatment; Stem cells -- Periodicals; Regenerative medicine -- Periodicals; Periodicals; 616.0277405
• DOI: 10.1002/sctm.19-0432
• Languages: English
• ISSNs: 2157-6564

Abstract

Abstract: Mesenchymal stromal cells (MSCs) offer great potential for the treatment of cardiovascular diseases (CVDs) such as myocardial infarction and heart failure. Studies have revealed that the efficacy of MSCs is mainly attributed to their capacity to secrete numerous trophic factors that promote angiogenesis, inhibit apoptosis, and modulate the immune response. There is growing evidence that MSC-derived extracellular vesicles (EVs) containing a cargo of lipids, proteins, metabolites, and RNAs play a key role in this paracrine mechanism. In particular, encapsulated microRNAs have been identified as important positive regulators of angiogenesis in pathological settings of insufficient blood supply to the heart, thus opening a new path for the treatment of CVD. In the present review, we discuss the current knowledge related to the proangiogenic potential of MSCs and MSC-derived EVs as well as methods to enhance their biological activities for improved cardiac tissue repair. Increasing our understanding of mechanisms supporting angiogenesis will help optimize future approaches to CVD intervention. : Abstract : Mesenchymal stromal cells (MSCs) offer tremendous potential for the treatment of cardiovascular disease. Their predominant mode-of action is the paracrine secretion of trophic factors and extracellular vesicles (EVs) that promote angiogenesis, inhibit apoptosis, and modulate immune responses. In this review, we discuss different strategies to enhance the angiogenic potential of MSCs and MSC-derived EVs for improved cardiac tissue repair.