Macrophage-derived exosomes accelerate wound healing through their anti-inflammation effects in a diabetic rat model. Issue 1 (4th December 2019)

• Record Type: Journal Article
• Authors: Li, Mengdie; Wang, Tao; Tian, He; Wei, Guohua; Zhao, Liang; Shi, Yijie
• Is Part Of: Artificial cells, nanomedicine, and biotechnology. Volume 47:Issue 1(2019)
• Page Start: 3793
• Page End: 3803
• Publication Date: 2019-12-04
• Subjects: Diabetes -- inflammation -- wound healing -- exosomes -- angiogenesis; Artificial cells -- Periodicals; Nanotechnology -- Periodicals; Blood substitutes -- Periodicals; Tissue engineering -- Periodicals; Molecules -- Periodicals; Biotechnology -- Periodicals; 615.39
• DOI: 10.1080/21691401.2019.1669617
• Languages: English
• ISSNs: 2169-1401

Abstract

Abstract: Chronic, subclinical inflammation was often observed in the diabetic wound area, causing inadequate and delayed wound-healing effects by failing to initiate cell migration, proliferation, and extracellular matrix deposition. Therefore, we presented macrophage-derived exosomes (Exos) and explored their potential for inhibiting inflammation and accelerating diabetic wound healing in a skin defect, diabetic rat model. A thorough investigation demonstrated that Exos exerted anti-inflammatory effects by inhibiting the secretion of pro-inflammatory enzymes and cytokines. Furthermore, they accelerated the wound-healing process by inducing endothelial cell proliferation and migration to improve angiogenesis and re-epithelialization in diabetic wounds.