Preparation of polyacrylamide/polylactic acid co-assembled core/shell nanofibers as designed beads for dapsone in vitro efficient delivery. Issue 1 (4th December 2019)

• Record Type: Journal Article
• Authors: Ranjbar, Mehdi; Khazaeli, Payam; Pardakhty, Abbas; Tahamipour, Batool; Amanatfard, Arezou
• Is Part Of: Artificial cells, nanomedicine, and biotechnology. Volume 47:Issue 1(2019)
• Page Start: 917
• Page End: 926
• Publication Date: 2019-12-04
• Subjects: Core/shell nanofibrous -- dapsone -- efficient drug delivery -- polyacrylamide/polylactic acid; Artificial cells -- Periodicals; Nanotechnology -- Periodicals; Blood substitutes -- Periodicals; Tissue engineering -- Periodicals; Molecules -- Periodicals; Biotechnology -- Periodicals; 615.39
• DOI: 10.1080/21691401.2019.1577881
• Languages: English
• ISSNs: 2169-1401

Abstract

Abstract: The main aim of this study is to synthesize and prepare polyacrylamide (PAM)/polylactic acid (PLA) co-assembled core/shell nanofibers in order to investigate an effective dapsone-loaded capability and dapsone-release in the aqueous medium. Dapsone (4, 4-diamino-diphenyl sulfone) has high permeability and low solubility in water. In vitro release testing indicates that maximum incorporation of the dapsone nanoemulsions into core/shell nanofibrous structures were 77.71 after 400 min. Products were characterized with X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Fourier Transform Infrared Spectroscopy (FT-IR), Thermo-Gravimetric Analysis (TGA), Dynamic light scattering (DLS) analysis, Contact Angle Measurement (CAM) and nitrogen adsorption [i.e. Brunauer-Emmett-Teller (BET) Surface Area Analysis] techniques. The porosimetric measurements of the nanofibers structures showed that high porosity diameter, adsorption cross-section area, pore volumes and dead volume were obtained as 0.162 nm 2, 0.1005 cm 3 g âˆ'1 and 15.693 cm 3, respectively. TGA curve of the core/shell nanofibrous structures shows thermal stability between 240 °C and 260 °C. Graphical Abstract: UF0001