Delayed graft function in pediatric living donor kidney transplantation. (11th November 2022)

• Record Type: Journal Article
• Authors: Hwang, Christine S.; Kadakia, Yash; Sanchez‐Vivaldi, Jorge A.; Patel, Madhukar S.; Shah, Jigesh A.; DeGregorio, Lucia; Desai, Dev M.; Vagefi, Parsia A.; MacConmara, Malcolm
• Is Part Of: Pediatric transplantation. Volume 27:Number 2(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-11-11
• Subjects: delayed graft function -- kidney -- living donor -- pediatrics; Transplantation of organs, tissues, etc. in children -- Periodicals; 617.95408305
• DOI: 10.1111/petr.14432
• Languages: English
• ISSNs: 1397-3142

Abstract

Abstract: Background: Pediatric recipients of living donor kidneys have a low rate of delayed graft function (DGF). We examined the incidence, risk factors and outcomes of DGF in pediatric patients who received a living donor allograft. Methods: The STARfile was queried to examine all pediatric patients transplanted with a living donor kidney between 2000 and 2020. Donor and recipient demographic data were examined, as were survival and outcomes. Recipients were stratified into DGF and no DGF groups. DGF was defined as the need for dialysis within the first week after transplant. Results: 6480 pediatric patients received a living donor (LD) kidney transplant during the study period. 269 (4.2%) developed DGF post‐transplant. Donors were similar in age, creatinine, and cold ischemia time. Recipients of kidneys with DGF were similar in age, sensitization status and HLA mismatch. Focal segmental glomerulosclerosis (FSGS) was the most common diagnosis in recipients with DGF, and allograft thrombosis was the most common cause of graft loss in this group. Small recipients (weight < 15 kg) were found to have a significantly higher rate of DGF. Length of stay doubled in recipients with DGF, and rejection rates were higher post‐transplant. Recipients of LD kidneys who developed DGF had significantly worse 1 year allograft survival (67% vs. 98%, p < .0001). Conclusions: Pediatric living donor kidney transplant recipients who experience DGF have significantly poorer allograft survival. Optimizing the donor and recipient matching to avoid compounding risks may allow for better outcomes.