Diagnostic and therapeutic management of vesico‐ureteral reflux in pediatric kidney transplantation—Results of an online survey on behalf of the European Society for Paediatric Nephrology. (7th December 2022)

• Record Type: Journal Article
• Authors: Zirngibl, Matthias; Buder, Kathrin; Luithle, Tobias; Tönshoff, Burkhard; Weitz, Marcus
• Other Names: Alonso‐Melgar Ángel investigator.; Ariceta Gema investigator.; Awan Atif investigator.; Bakkaloglu Sevcan A. investigator.; Baskin Esra investigator.; Bekassy Zivile investigator.; Bhimma Rajendra investigator.; Bitzan Martin investigator.; Bjerre Anna Kristina investigator.; Bootsma‐Robroeks Charlotte M. investigator.; Bouts Antonia investigator.; Büscher Anja investigator.; Bulum Burcu investigator.; Christian Martin investigator.; Cicek Neslihan investigator.; Clothier Joanna investigator.; Cornelissen Marlies investigator.; Dehoux Laurène investigator.; Kılıç Beltinge Demircioğlu investigator.; Dinçel Nida Temizkan investigator.; Esfandiar Nasrin investigator.; Espinosa‐Román Laura investigator.; Fila Marc investigator.; Galiano Matthias investigator.; Gander Romy investigator.; Gessner Michaela investigator.; Grenda Ryszard investigator.; Henne Thomas investigator.; Herthelius Maria investigator.; Goñi Maria Herrero investigator.; Higueras Walter investigator.; Hooman Nakisa investigator.; Jahnukainen Timo investigator.; Jankauskiene Augustina investigator.; de Jong Huib investigator.; Knops Noël investigator.; Konrad Martin investigator.; Levtchenko Elena investigator.; Madrid‐Aris Alvaro investigator.; Marks Stephen D. investigator.; Mattoo Tej K. investigator.; Maxted Andrew investigator.; Melgosa‐Hijosa Marta investigator.; Mincham Christine Marie investigator.; Mitsioni Andromachi investigator.; Montini Giovanni investigator.; Morgan Henry investigator.; Müller‐Sacherer Thomas investigator.; Murer Luisa investigator.; Özçakar Z Birsin investigator.; Pape Lars investigator.; Parvex Paloma investigator.; Printza Nikoleta investigator.; Prytula Agnieszka investigator.; Reynolds Ben investigator.; Roussinov Dimitar investigator.; Rubik Jacek investigator.; Rumyantsev Alexander investigator.; Rus Rina investigator.; Seeman Tomas investigator.; Shenoy Mohan investigator.; Silva Ana Cristina Simões E. investigator.; Sinha Rajiv investigator.; Stabouli Stella investigator.; Taşdemir Mehmet investigator.; Tasic Velibor investigator.; Teixeira Ana investigator.; Thumfart Julia investigator.; Topaloğlu Rezan investigator.; Torres Diletta investigator.; Trnka Peter investigator.; Tschumi Sibylle investigator.; Tse Yincent investigator.; Aki Fazil Tuncay investigator.; Verrina Enrico Eugenio investigator.; Vidal Enrico investigator.; Weber Lutz T. investigator.; Yalçınkaya Fatma Fatoş investigator.; Yap Yok‐Chin investigator.; Yıldız Nurdan investigator.; Yüksel Selçuk investigator.; Zieg Jakub investigator.;
• Is Part Of: Pediatric transplantation. Volume 27:Number 2(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-12-07
• Subjects: febrile urinary tract infection -- online survey -- pediatric kidney transplantation -- therapy -- ureteral implantation -- vesico‐ureteral reflux; Transplantation of organs, tissues, etc. in children -- Periodicals; 617.95408305
• DOI: 10.1111/petr.14449
• Languages: English
• ISSNs: 1397-3142

Abstract

Abstract: Background: Vesico‐ureteral reflux (VUR) is considered to be a risk factor for recurrent febrile urinary tract infections and impaired renal transplant survival. Methods: An online survey supported by the European Society for Paediatric Nephrology was designed to evaluate current management strategies of VUR in native and transplanted kidneys of recipients aged <18 years. Results: Seventy‐three pediatric transplant centers from 32 countries contributed to the survey. All centers performed urological evaluation prior to pediatric kidney transplantation (KTx) with subsequent interdisciplinary discussion. Screening for VUR in native kidneys (30% in all, 70% in selected patients) led to surgical intervention in 78% (11% in all, 89% in selected patients) with a decided preference of endoscopic intervention over ureterocystoneostomy. Following KTx, continuous antibiotic prophylaxis was applied in 65% of the patients and screening for allograft VUR performed in 93% of selected patients. The main management strategies of symptomatic allograft VUR were continuous antibiotic prophylaxis (83%) and surgical treatment (74%) (endoscopic intervention 55%, redo ureterocystoneostomy 26%). Conclusions: This survey demonstrates the high variability in the management of VUR in pediatric KTx recipients, points to knowledge gaps, and might serve as a starting point for improving the care for patients with VUR in native and transplanted kidneys.