Intraoperative Frozen Biopsy for the Evaluation of Extrathyroidal Extension in Papillary Thyroid Cancer. (2nd September 2014)

• Record Type: Journal Article
• Authors: Park, Young Min; Park, Young Dae; Lee, Won Yong; Lee, Jin‐Choon; Wang, Soo‐Geun; Lee, Byung‐Joo
• Is Part Of: Otolaryngology--head and neck surgery. Volume 151(2014)Supplement 1
• Page Start: P172
• Page End: P172
• Publication Date: 2014-09-02
• Subjects: Head -- Surgery -- Periodicals; Neck -- Surgery -- Periodicals; Otolaryngology -- Periodicals; 617.51
• DOI: 10.1177/0194599814541629a108
• Languages: English
• ISSNs: 0194-5998

Abstract

Abstract : Objectives: We investigated extrathyroidal extension (ETE) through frozen biopsy for intraoperative decision‐making in patients with papillary thyroid cancer (PTC). Methods: During the period of the study an operation was performed in 268 patients with PTC and ETE was evaluated using intraoperative frozen biopsies of thyroid tissue. Results: ETE was confirmed in 54 patients (20%) on frozen biopsy. Fifty‐three patients among 54 patients showing ETE on frozen biopsy were confirmed on permanent pathologic analysis. Accordingly, frozen biopsy had a sensitivity of 66%, a specificity of 99%, a positive predictive value of 98%, and a negative predictive value of 87%. Tumor size (odds ratio 4.373; confidence interval 2.257‐8.475, P <. 001) was an independent factor for predicting ETE on frozen biopsy. Conclusions: Intraoperative frozen biopsy can be a useful tool in identifying the presence of ETE. It can also help the operator decide the extent of surgery and central neck dissection in patients with PTC.