Signaling mechanism of the netrin-1 receptor DCC in axon guidance. Issue 3 (September 2015)

• Record Type: Journal Article
• Authors: Finci, L.; Zhang, Y.; Meijers, R.; Wang, J.-H.
• Is Part Of: Progress in biophysics and molecular biology. Volume 118:Issue 3(2015)
• Page Start: 153
• Page End: 160
• Publication Date: 2015-09
• Subjects: DCC -- Netrin-1 -- Axon guidance -- Structure -- UNC5; Biophysics -- Periodicals; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular Biology -- Periodicals; Biophysique -- Périodiques; Biochimie -- Périodiques; 571.4
• DOI: 10.1016/j.pbiomolbio.2015.04.001
• Languages: English
• ISSNs: 0079-6107

Abstract

Abstract: DCC (Deleted in Colorectal Cancer) is a single-pass transmembrane protein that belongs to the immunoglobulin superfamily. It was originally identified as a prognostic tumor marker and then subsequently found to be a receptor for netrin-1. DCC plays a key role in axon guidance and also in a number of other important cellular processes. This review describes the current progress of the structural biology of DCC with an emphasis on how DCC is involved in the dual functionality of netrin-1 as a chemo-attractant as well as a repellent in axon guidance, referred to as bi-functionality. A perspective about other DCC ligands and the signaling mechanism of the cytoplasmic tail of DCC is also recapitulated.