A Forward Vision for Chemodynamic Therapy: Issues and Opportunities. (17th January 2023)

• Record Type: Journal Article
• Authors: Zhao, Peiran; Li, Huiyan; Bu, Wenbo
• Is Part Of: Angewandte Chemie. Volume 135:Number 7(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-01-17
• Subjects: chemodynamic therapy -- Fenton chemistry -- hydroxyl radical -- nanomedicine -- cellular spatiotemporal mechanism; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.202210415
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Since the insight to fuse Fenton chemistry and nanomedicine into cancer therapy, great signs of progress have been made in the field of chemodynamic therapy (CDT). However, the exact mechanism of CDT is obscured by the unique tumor chemical environment and inevitable nanoparticle‐cell interactions, thus impeding further development. In this Scientific Perspective, the significance of CDT is clarified, the complex mechanism is deconstructed into primitive chemical and biological interactions, and the mechanism research directions based on the chemical kinetics and biological signaling pathways are discussed in detail. Moreover, beneficial outlooks are presented to enlighten the evolution of next‐generation CDT. Hopefully, this Scientific Perspective can inspire new ideas and advances for CDT and provide a reference for breaking down the interdisciplinary barriers in the field of nanomedicine. Abstract : Chemodynamic therapy (CDT) that integrates Fenton chemistry and biomedicine provides strategies for cancer treatment with nanomedicine; however, the exact mechanism of CDT is not fully understood. In this Scientific Perspective, the conceptual framework of CDT is clarified and research approaches that illuminate its chemical and biological mechanisms are discussed. Beneficial outlooks for CDT are provided to inspire new advances in the field.