Physical activity and brain health in patients with atrial fibrillation. (28th December 2022)

• Record Type: Journal Article
• Authors: Herber, Elena; Aeschbacher, Stefanie; Coslovsky, Michael; Schwendinger, Fabian; Hennings, Elisa; Gasser, Andreas; Di Valentino, Marcello; Rigamonti, Elia; Reichlin, Tobias; Rodondi, Nicolas; Netzer, Seraina; Beer, Juerg H.; Stauber, Annina; Müller, Andreas; Ammann, Peter; Sinnecker, Tim; Duering, Marco; Wuerfel, Jens; Conen, David; Kühne, Michael; Osswald, Stefan; Bonati, Leo H.
• Other Names: Herber Elena investigator.; Aeschbacher Stefanie investigator.; Coslovsky Michael investigator.; Schwendinger Fabian investigator.; Hennings Elisa investigator.; Gasser Andreas investigator.; Di Valentino Marcello investigator.; Rigamonti Elia investigator.; Reichlin Tobias investigator.; Rodondi Nicolas investigator.; Netzer Seraina investigator.; Beer Juerg H investigator.; Stauber Annina investigator.; Müller Andreas investigator.; Ammann Peter investigator.; Sinnecker Tim investigator.; Duering Marco investigator.; Wuerfel Jens investigator.; Conen David investigator.; Kühne Michael investigator.; Osswald Stefan investigator.; Bonati Leo H investigator.; Auberson Chloé investigator.; Blum Steffen investigator.; Bonati Leo investigator.; Ceylan Selinda investigator.; Evers‐Doerpfeld Simone investigator.; Eken Ceylan investigator.; Girod Marc investigator.; Iten Vasco investigator.; Krisai Philipp investigator.; Lampart Maurin investigator.; Lischer Mirko investigator.; Meyer‐Zürn Christine investigator.; Meyre Pascal investigator.; Monsch Andreas U. investigator.; Müller Christian investigator.; Paladini Rebecca E. investigator.; Springer Anne investigator.; Sticherling Christian investigator.; Szucs Thomas investigator.; Völlmin Gian investigator.; Osswald Stefan investigator.; Kühne Michael investigator.; Aujesky Drahomir investigator.; Fischer Urs investigator.; Fuhrer Juerg investigator.; Roten Laurent investigator.; Jung Simon investigator.; Mattle Heinrich investigator.; Adam Luise investigator.; Aubert Carole Elodie investigator.; Feller Martin investigator.; Loewe Axel investigator.; Moutzouri Elisavet investigator.; Schneider Claudio investigator.; Flückiger Tanja investigator.; Groen Cindy investigator.; Ehrsam Lukas investigator.; Hellrigl Sven investigator.; Nuoffer Alexandra investigator.; Rakovic Damiana investigator.; Schwab Nathalie investigator.; Wenger Rylana investigator.; Saffari Tu Hanh Zarrabi investigator.; Beynon Christopher investigator.; Dillier Roger investigator.; Deubelbeiss Michèle investigator.; Eberli Franz investigator.; Franzini Christine investigator.; Juchli Isabel investigator.; Liedtke Claudia investigator.; Murugiah Samira investigator.; Nadler Jacqueline investigator.; Obst Thayze investigator.; Roth Jasmin investigator.; Schlomowitsch Fiona investigator.; Schneider Xiaoye investigator.; Studerus Katrin investigator.; Tynan Noreen investigator.; Weishaupt Dominik investigator.; Fontana Simone investigator.; Friedli Corinne investigator.; Kuest Silke investigator.; Scheuch Karin investigator.; Hischier Denise investigator.; Bonetti Nicole investigator.; Grau Alexandra investigator.; Villinger Jonas investigator.; Laube Eva investigator.; Baumgartner Philipp investigator.; Filipovic Mark investigator.; Frick Marcel investigator.; Montrasio Giulia investigator.; Leuenberger Stefanie investigator.; Rutz Franziska investigator.; Beer Jürg‐Hans investigator.; Auricchio Angelo investigator.; Anesini Adriana investigator.; Camporini Cristina investigator.; Conte Giulio investigator.; Caputo Maria Luce investigator.; Regoli Francois investigator.; Moccetti Tiziano investigator.; Brenner Roman investigator.; Altmann David investigator.; Gemperle Michaela investigator.; Firmann Mathieu investigator.; Foucras Sandrine investigator.; Rime Martine investigator.; Hayoz Daniel investigator.; Berte Benjamin investigator.; Justi Virgina investigator.; Kellner‐Weldon Frauke investigator.; Mehmann Brigitta investigator.; Meier Sonja investigator.; Roth Myriam investigator.; Ruckli‐Kaeppeli Andrea investigator.; Russi Ian investigator.; Schmidt Kai investigator.; Young Mabelle investigator.; Zbinden Melanie investigator.; Kobza Richard investigator.; Cereda Carlo investigator.; Cianfoni Alessandro investigator.; De Perna Maria Luisa investigator.; Frangi‐Kultalahti Jane investigator.; Melchiorre Patrizia Assunta Mayer investigator.; Pin Anica investigator.; Terrot Tatiana investigator.; Vicari Luisa investigator.; Moschovitis Giorgio investigator.; Ehret Georg investigator.; Gallet Hervé investigator.; Guillermet Elise investigator.; Lazeyras Francois investigator.; Lovblad Karl‐Olof investigator.; Perret Patrick investigator.; Tavel Philippe investigator.; Teres Cheryl investigator.; Shah Dipen investigator.; Lauriers Nathalie investigator.; Méan Marie investigator.; Salzmann Sandrine investigator.; Schläpfer Jürg investigator.; Porretta Alessandra Pia investigator.; Grêt Andrea investigator.; Novak Jan investigator.; Vitelli Sandra investigator.; Stephan Frank‐Peter investigator.; Frangi‐Kultalahti Jane investigator.; Gallino Augusto investigator.; Vicari Luisa investigator.; Aebersold Helena investigator.; Foster Fabienne investigator.; Schwenkglenks Matthias investigator.; Altermatt Anna investigator.; Amann Michael investigator.; Düring Marco investigator.; Huber Petra investigator.; Ruberte Esther investigator.; Zuber Vanessa investigator.; Benkert Pascal investigator.; Dutilh Gilles investigator.; Markovic Milica investigator.; Neuschwander Pia investigator.; Simon Patrick investigator.; Schmid Ramun investigator.;
• Is Part Of: European journal of neurology. Volume 30:Number 3(2023)
• Page Start: 567
• Page End: 577
• Publication Date: 2022-12-28
• Subjects: atrial fibrillation -- cerebral infarction -- cerebral microbleeds -- cognitive disorders and dementia -- neurocognitive function -- physical activity -- total brain volume -- white matter disease; Neurology -- Periodicals; Nervous system -- Diseases -- Periodicals; 616.8
• DOI: 10.1111/ene.15660
• Languages: English
• ISSNs: 1351-5101

Abstract

Abstract: Background and purpose: Vascular brain lesions, such as ischemic infarcts, are common among patients with atrial fibrillation (AF) and are associated with impaired cognitive function. The role of physical activity (PA) in the prevalence of brain lesions and cognition in AF has not been investigated. Methods: Patients from the multicenter Swiss‐AF cohort study were included in this cross‐sectional analysis. We assessed regular exercise (RE; at least once weekly) and minutes of weekly PA using a validated questionnaire. We studied associations with ischemic infarcts, white matter hyperintensities, cerebral microbleeds, and brain volume on brain magnetic resonance imaging and with global cognition measured with a cognitive construct (CoCo) score. Results: Among 1490 participants (mean age = 72 ± 9 years), 730 (49%) engaged in RE. In adjusted regression analyses, RE was associated with a lower prevalence of ischemic infarcts (odds ratio [OR] = 0.78, 95% confidence interval [CI] = 0.63–0.98, p = 0.03) and of moderate to severe white matter hyperintensities (OR = 0.78, 95% CI = 0.62–0.99, p = 0.04), higher brain volume ( β ‐coefficient = 10.73, 95% CI = 2.37–19.09, p = 0.01), and higher CoCo score ( β ‐coefficient = 0.08, 95% CI = 0.03–0.12, p < 0.001). Increasing weekly PA was associated with higher brain volume ( β ‐coefficient = 1.40, 95% CI = 0.65–2.15, p < 0.001). Conclusions: In AF patients, RE was associated with a lower prevalence of ischemic infarcts and of moderate to severe white matter disease, with larger brain volume, and with better cognitive performance. Prospective studies are needed to investigate whether these associations are causal. Until then, our findings suggest that patients with AF should be encouraged to remain physically active. Abstract : The importance of physical activity in the prevalence of brain lesions, brain volume, and cognitive function among patients with atrial fibrillation is unknown. Participants from the multicenter Swiss‐AF cohort study were included in this cross‐sectional analysis. In atrial fibrillation patients, regular exercise was associated with a lower prevalence of ischemic infarcts and of moderate to severe white matter disease, with larger brain volume, and with better cognitive performance.