Cordycepin inhibited the retinoblastoma cell proliferation, migration, and invasion as well as lung metastasis via modulating c‐Myc/cyclin D1 pathway. (14th October 2022)

• Record Type: Journal Article
• Authors: Min, Yao; Ding, Yi; Huang, Qing; Xu, Ya; Li, Jing
• Is Part Of: Chemical biology & drug design. Volume 101:Number 3(2023)
• Page Start: 605
• Page End: 613
• Publication Date: 2022-10-14
• Subjects: c‐Myc -- cordycepin -- invasion -- migration -- proliferation; Drugs -- Design -- Periodicals; Pharmaceutical chemistry -- Periodicals; Biochemistry -- Periodicals; 615.19005
• DOI: 10.1111/cbdd.14150
• Languages: English
• ISSNs: 1747-0277

Abstract

Abstract: This study aims to investigate cordycepin's effects on the proliferation, migration, and invasion of retinoblastoma (RB) cells and its regulatory mechanism. In this study, it was found that cordycepin inhibited RB cell proliferation, migration, and invasion in vitro, and pulmonary metastasis in vivo. c‐Myc was a downstream target of cordycepin, and cordycepin significantly suppressed c‐Myc expression, and c‐Myc overexpression markedly counteracted the impacts of cordycepin on RB cell proliferation, migration, and invasion. c‐Myc was positively correlated with the cell cycle pathway. Cordycepin restrained cyclin D1 expression, and c‐Myc overexpression rescued this effect. In conclusion, cordycepin targets the c‐Myc/cyclin D1 pathway, thereby suppressing the malignant biological behaviors of RB cells. Abstract : Cordycepin inhibited Rb cell proliferation, migration, and invasion. c‐Myc is a downstream target of cordycepin, cordycepin significantly suppressed c‐Myc expression, and c‐Myc overexpression markedly counteracted the impacts of cordycepin on Rb cell proliferation, migration, and invasion.