Beta-Band Modulation Differentiates Between Movement Execution and Inhibition in the Human Hippocampus. (16th November 2020)

• Record Type: Journal Article
• Authors: Gogia, Angad S; del Campo-Vera, Roberto M; Chen, Kuang-Hsuan; Sebastian, Rinu; Nune, George; Tang, Austin M; Kramer, Daniel R; Lee, Morgan B; Liu, Charles Y; Kellis, Spencer; Lee, Brian
• Is Part Of: Neurosurgery. Volume 67(2010)Supplement 1
• Publication Date: 2020-11-16
• Subjects: Nervous system -- Surgery -- Periodicals; 617.48005
• DOI: 10.1093/neuros/nyaa447_656
• Languages: English
• ISSNs: 0148-396X

Abstract

Abstract: INTRODUCTION: The human hippocampus is thought to be involved in movement, but its precise role in movement execution and inhibition has not been well studied. Previous work with direct neural recordings has found beta-band (13-30 Hz) modulation in both movement execution and inhibition throughout the motor system, but the role of beta-band modulation in the hippocampus is unknown. Here we perform a go/no go reaching task in eight patients with medically-refractory epilepsy to study human hippocampal beta-power changes during movement. METHODS: Eight epilepsy patients (6 female; ages 21–47) were implanted with intracranial depth electrodes for seizure monitoring and localization. Local field potentials were sampled at 2000 Hz during a go/no go reaching movement task. Non-overlapping bootstrapped (n = 10, 000) confidence intervals (α = 0.05) were used to determine statistical significance for beta-band power during movement execution and inhibition. RESULTS: In six out of eight patients, we observed a statistically significant decrease in trial-averaged beta-band power during the execution of movement. During movement inhibition, five patients had an increase in trial-averaged beta-band power, three of which were statistically significant. CONCLUSION: These findings indicate that beta-band power differentiates between movement execution and inhibition in the human hippocampus. To our knowledge, this is the first time that beta-band modulation has been shown to play a role in motor control and movement inhibition in the human hippocampus using direct electrophysiological recordings.