A spontaneous coronary arterial dissection associated with a calcineurin inhibitor. (10th July 2012)

• Record Type: Journal Article
• Authors: Mallon, Dermot Henry; McKenzie, Daniel; Dayer, Mark
• Is Part Of: BMJ case reports. Volume 2012
• Publication Date: 2012-07-10
• Subjects: Medicine -- Case studies -- Periodicals; 610.5
• DOI: 10.1136/bcr-2012-006414
• Languages: English
• ISSNs: 1757-790X

Abstract

Abstract : We present the case of a 55-year-old lady presenting 5 months after a liver transplant with acute coronary syndrome. She was on maintenance-dose tacrolimus. An angiogram diagnosed a spontaneous coronary artery dissection, which was successfully stented. This is the third case in the literature associating a calcineurin inhibitor with a spontaneous coronary arterial dissection. The detrimental effect of calcineurin inhibitors on vasculature is well recognised. This report highlights their potentially serious side-effects. It should be appreciated that calcineurin inhibitors have the potential to cause or contribute to this rare vascular phenomenon and the diagnosis should therefore be considered in those taking such drugs.