Restoration of FMRP expression in adult V1 neurons rescues visual deficits in a mouse model of fragile X syndrome. Issue 3 (29th October 2021)

• Record Type: Journal Article
• Authors: Yang, Chaojuan; Tian, Yonglu; Su, Feng; Wang, Yangzhen; Liu, Mengna; Wang, Hongyi; Cui, Yaxuan; Yuan, Peijiang; Li, Xiangning; Li, Anan; Gong, Hui; Luo, Qingming; Zhu, Desheng; Cao, Peng; Liu, Yunbo; Wang, Xunli; Luo, Min-hua; Xu, Fuqiang; Xiong, Wei; Wang, Liecheng; Li, Xiang-yao; Zhang, Chen
• Is Part Of: Protein & cell. Volume 13:Issue 3(2022)
• Page Start: 203
• Page End: 219
• Publication Date: 2021-10-29
• Subjects: autism spectrum disorder -- calcium imaging -- fragile X syndrome -- primary visual cortex -- visual hypersensitivity; Proteins -- Periodicals; Cells -- Periodicals; Cytology -- Periodicals; 572.6
• DOI: 10.1007/s13238-021-00878-z
• Languages: English
• ISSNs: 1674-800X

Abstract

ABSTRACT: Many people affected by fragile X syndrome (FXS) and autism spectrum disorders have sensory processing deficits, such as hypersensitivity to auditory, tactile, and visual stimuli. Like FXS in humans, loss of Fmr1 in rodents also cause sensory, behavioral, and cognitive deficits. However, the neural mechanisms underlying sensory impairment, especially vision impairment, remain unclear. It remains elusive whether the visual processing deficits originate from corrupted inputs, impaired perception in the primary sensory cortex, or altered integration in the higher cortex, and there is no effective treatment. In this study, we used a genetic knockout mouse model ( Fmr1 KO ), in vivo imaging, and behavioral measurements to show that the loss of Fmr1 impaired signal processing in the primary visual cortex (V1). Specifically, Fmr1 KO mice showed enhanced responses to low-intensity stimuli but normal responses to high-intensity stimuli. This abnormality was accompanied by enhancements in local network connectivity in V1 microcircuits and increased dendritic complexity of V1 neurons. These effects were ameliorated by the acute application of GABAA receptor activators, which enhanced the activity of inhibitory neurons, or by reintroducing Fmr1 gene expression in knockout V1 neurons in both juvenile and young-adult mice. Overall, V1 plays an important role in the visual abnormalities of Fmr1 KO mice and it could be possible to rescue the sensory disturbances in developed FXS and autism patients.