Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults. (10th September 2020)

• Record Type: Journal Article
• Authors: Chen, Sijia; Pawelec, Graham; Trompet, Stella; Goldeck, David; Mortensen, Laust H; Slagboom, P Eline; Christensen, Kaare; Gussekloo, Jacobijn; Kearney, Patricia; Buckley, Brendan M; Ford, Ian; Jukema, J Wouter; Westendorp, Rudi G J; Maier, Andrea B
• Is Part Of: Journal of infectious diseases. Volume 223:Number 2(2021)
• Page Start: 238
• Page End: 246
• Publication Date: 2020-09-10
• Subjects: Herpesviridae -- cytomegalovirus -- seroepidemiologic studies -- immunoglobulin G -- mortality -- cardiovascular -- aged; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiaa480
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: Background: Whether latent cytomegalovirus (CMV) infection in older adults has any substantial health consequences is unclear. Here, we sought associations between CMV-seropositivity and IgG titer with all-cause and cardiovascular mortality in 5 longitudinal cohorts. Methods: Leiden Longevity Study, Prospective Study of Pravastatin in the Elderly at Risk, Longitudinal Study of Aging Danish Twins, and Leiden 85-plus Study were assessed at median (2.8–11.4 years) follow-up . Cox regression and random effects meta-analysis were used to estimate mortality risk dependent on CMV serostatus and/or IgG antibody titer, in quartiles after adjusting for confounders. Results: CMV-seropositivity was seen in 47%–79% of 10 122 white community-dwelling adults aged 59–93 years. Of these, 3519 had died on follow-up (579 from cardiovascular disease). CMV seropositivity was not associated with all-cause (hazard ratio [HR], 1.05; 95% confidence interval [CI], .97–1.14) or cardiovascular mortality (HR, 0.97; 95% CI, .83–1.13). Subjects in the highest CMV IgG quartile group had increased all-cause mortality relative to CMV-seronegatives (HR, 1.16; 95% CI, 1.04–1.29) but this association lost significance after adjustment for confounders (HR, 1.13; 95% CI, .99–1.29). The lack of increased mortality risk was confirmed in subanalyses. Conclusions: CMV infection is not associated with all-cause or cardiovascular mortality in white community-dwelling older adults. Abstract : CMV infection is not associated with all-cause or cardiovascular mortality in Caucasian community-dwelling older adults.