Deaminative defluoroalkylation of α-trifluoromethylalkenes enabled by photoredox catalysis. Issue 2 (13th December 2022)

• Record Type: Journal Article
• Authors: Zhang, Guodong; Wang, Lei; Cui, Liping; Gao, Pan; Chen, Feng
• Is Part Of: Organic & biomolecular chemistry. Volume 21:Issue 2(2023)
• Page Start: 294
• Page End: 299
• Publication Date: 2022-12-13
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d2ob02114e
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A new photoredox-catalysed strategy to construct gem -difluoroallylarenes from α-trifluoromethylalkenes and primary amines has been developed. This deaminative defluoroallylation is compatible with sterically hindered α-3° and 2° primary amines. Abstract : Herein, we disclose a new photoredox-catalysed strategy to access gem -difluoroallylarenes from α-trifluoromethylalkenes with sterically hindered primary amines via C–N and C–F bond activation. This deaminative and defluorinative allylation is generally compatible with diverse functional groups and sterically hindered α-3° and 2° primary amines.