Study of "ALS reversals": LifeTime environmental exposures (StARLiTE). Issue 1 (2nd January 2023)

• Record Type: Journal Article
• Authors: Crayle, J.; Lutz, M.; Raymond, J.; Mehta, P.; Bedlack, R.
• Is Part Of: Amyotrophic lateral sclerosis and frontotemporal degeneration. Volume 24:Issue 1/2(2023)
• Page Start: 54
• Page End: 62
• Publication Date: 2023-01-02
• Subjects: Amyotrophic lateral sclerosis -- epidemiology -- risk -- survival; 616.839
• DOI: 10.1080/21678421.2022.2090846
• Languages: English
• ISSNs: 2167-8421

Abstract

Abstract: We previously reported on a series of patients diagnosed with ALS whom had an extraordinary course defined by substantial and sustained improvement in weakness and function. For this study, twenty-five of these "ALS Reversals" completed extensive environmental exposure questionnaires. These responses were then compared to a large database of prior responses from patients with typically progressive ALS ( n = 6187). The results demonstrated that the "Reversal" participants have had a diverse number of exposures with substantial heterogeneity. In general, this was similar to the control group; however, there were a few specific differences that could be further explored in future research.